Agnati L F, Cortelli P, Biagini G, Bjelke B, Fuxe K
Department of Human Physiology, University of Modena, Italy.
Neuroreport. 1994 Dec 30;6(1):9-12. doi: 10.1097/00001756-199412300-00004.
Volume transmission (VT) is the mode of intercellular communication involving the diffusion of transmitters, via extracellular fluid (ECF) pathways, from nerve cells selectively capable of producing the signal (signal source) to nerve and glial cells selectively capable of recognizing it (signal target). The proposal is now put forward that at least two classes of VT signals can be distinguished: (a) the private-code signals, exemplified by neurotransmitters, which are released by a limited group of nerve cells and recognized, via high affinity G-protein coupled receptors or by cytosolic enzymes such as guanylate cyclase in the case of nitric oxide, by a specific group of cells; and (b) the accessible-code signals, such as the electrical signals that are released by all neuronal cells and decoded by almost every CNS cell. In the present paper, it will be underlined that carbon dioxide, hydrogen ions, temperature gradients and pressure waves may be regulators of wiring transmission and VT.
容积传输（VT）是一种细胞间通讯方式，涉及递质通过细胞外液（ECF）途径从有能力选择性产生信号的神经细胞（信号源）扩散到有能力选择性识别该信号的神经细胞和神经胶质细胞（信号靶）。现在提出这样一个观点，即至少可以区分两类容积传输信号：（a）专用编码信号，以神经递质为例，由有限的一组神经细胞释放，并通过高亲和力G蛋白偶联受体或在一氧化氮的情况下通过胞质酶如鸟苷酸环化酶被特定的一组细胞识别；（b）通用编码信号，如所有神经元细胞释放并被几乎每个中枢神经系统细胞解码的电信号。在本文中，将强调二氧化碳、氢离子、温度梯度和压力波可能是线路传输和容积传输的调节因子。
