Proenza A M, Palou A, Roca P
Dept. de Biologia Fonamental i Ciències de la Salut (Biologia Molecular, Nutrició i Biotecnologia), Universitat de les Illes Balears, Palma de Mallorca, Spain.
Biochem Mol Biol Int. 1994 Nov;34(5):971-82.
The recently published existence of a pool of amino acids absorbed onto the blood cell membranes in the rat has provided a new insight into the role of the blood cell amino acid pools, in the context of tissue-blood amino acid transport and their metabolic relationships. In the present study, this pool has been measured in a large (n = 40) representative healthy human population. This pool represents 9% of the blood cell amino acids, which is somewhat lower but in the same order as that previously measured in the rat. The inside-erythrocyte and plasma pools have also been quantified, giving an inside to outside ratio of 1.32 for the combined total amino acids. Statistically significant age related changes in the different blood compartments were detected for some amino acids (aspartate, asparagine, glutamine, tyrosine, methionine, phenylalanine, tryptophan and lysine) as well as for the ratio of tryptophan to the large neutral amino acids. The results obtained emphasize the importance of the amino acid red blood cell pool and assign to it the same order as the plasma pool. The results also feature the membrane-attached pool of some specific amino acids, ie taurine, glutamine, glutamate, aspartate and valine.
最近发表的关于大鼠血细胞细胞膜上吸附有一组氨基酸的研究成果，为血细胞氨基酸池在组织 - 血液氨基酸转运及其代谢关系中的作用提供了新的见解。在本研究中，已对大量（n = 40）具有代表性的健康人群进行了该氨基酸池的测量。这个氨基酸池占血细胞氨基酸的9%，略低于先前在大鼠中测得的比例，但处于同一量级。还对红细胞内和血浆中的氨基酸池进行了定量，得出总氨基酸的胞内与胞外比例为1.32。对于某些氨基酸（天冬氨酸、天冬酰胺、谷氨酰胺、酪氨酸、蛋氨酸、苯丙氨酸、色氨酸和赖氨酸）以及色氨酸与大中性氨基酸的比例，在不同血液成分中检测到了与年龄相关的具有统计学意义的变化。所得结果强调了红细胞氨基酸池的重要性，并赋予其与血浆池相同的量级。结果还突出了一些特定氨基酸（即牛磺酸、谷氨酰胺、谷氨酸、天冬氨酸和缬氨酸）的膜附着池。
