乳脂肪球膜对环孢素衍生物肠道吸收的增强作用。

Enhancement of the intestinal absorption of a cyclosporine derivative by milk fat globule membrane.

作者信息

Sato H, Liu H X, Adachi I, Ueno M, Lemaire M, Horikoshi I

机构信息

Department of Hospital Pharmacy, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.

出版信息

Biol Pharm Bull. 1994 Nov;17(11):1526-8. doi: 10.1248/bpb.17.1526.

DOI:10.1248/bpb.17.1526

PMID:7703979

Abstract

A cyclosporine derivative, dihydrocyclosporine D, was used for the evaluation of milk fat globule membrane (MFGM) as an emulsifier of lipophilic cyclopeptides. As compared with olive oil formulation, MFGM emulsion significantly enhanced the blood and lymphatic fluid concentrations of the cyclosporine derivative after intraduodenal dosing in rats. Thus, it was suggested that MFGM can be used as an intestinal absorption enhancer of cyclosporines.

摘要

一种环孢素衍生物，二氢环孢素D，被用于评估乳脂肪球膜（MFGM）作为亲脂性环肽乳化剂的性能。与橄榄油制剂相比，在大鼠十二指肠给药后，MFGM乳液显著提高了环孢素衍生物在血液和淋巴液中的浓度。因此，有人提出MFGM可作为环孢素的肠道吸收增强剂。