Enhancement of the intestinal absorption of a cyclosporine derivative by milk fat globule membrane.

作者信息

Sato H, Liu H X, Adachi I, Ueno M, Lemaire M, Horikoshi I

机构信息

Department of Hospital Pharmacy, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.

出版信息

Biol Pharm Bull. 1994 Nov;17(11):1526-8. doi: 10.1248/bpb.17.1526.

DOI:10.1248/bpb.17.1526

PMID:7703979

Abstract

A cyclosporine derivative, dihydrocyclosporine D, was used for the evaluation of milk fat globule membrane (MFGM) as an emulsifier of lipophilic cyclopeptides. As compared with olive oil formulation, MFGM emulsion significantly enhanced the blood and lymphatic fluid concentrations of the cyclosporine derivative after intraduodenal dosing in rats. Thus, it was suggested that MFGM can be used as an intestinal absorption enhancer of cyclosporines.

摘要