A rational approach to the use of topical antiseptics.

The proper application of antiseptics to the open wound is controversial. With the goal of creating an optimal environment for wound repair, consideration of a topical antiseptic includes both its bactericidal activity and its potential cytotoxicity when applied to the healing wound in varying concentrations. This discussion reviews the events of wound healing, including the key cells that mediate this process, the significance of bacteria in the wound bed, and the impact of infection. Specific antiseptics, including povidone-iodine, hydrogen peroxide, acetic acid, and Dakin's solution are reviewed, emphasizing their bactericidal potential and their cytotoxic properties.