Doughty D
J Wound Ostomy Continence Nurs. 1994 Nov;21(6):224-31. doi: 10.1097/00152192-199411000-00008.
The proper application of antiseptics to the open wound is controversial. With the goal of creating an optimal environment for wound repair, consideration of a topical antiseptic includes both its bactericidal activity and its potential cytotoxicity when applied to the healing wound in varying concentrations. This discussion reviews the events of wound healing, including the key cells that mediate this process, the significance of bacteria in the wound bed, and the impact of infection. Specific antiseptics, including povidone-iodine, hydrogen peroxide, acetic acid, and Dakin's solution are reviewed, emphasizing their bactericidal potential and their cytotoxic properties.
将防腐剂适用于开放性伤口存在争议。为了为伤口修复创造最佳环境，在考虑使用局部防腐剂时，既要考虑其杀菌活性，也要考虑其以不同浓度应用于正在愈合的伤口时的潜在细胞毒性。本讨论回顾了伤口愈合过程，包括介导这一过程的关键细胞、伤口床中细菌的意义以及感染的影响。还对包括聚维酮碘、过氧化氢、乙酸和达金氏溶液在内的特定防腐剂进行了综述，重点强调了它们的杀菌潜力和细胞毒性特性。
