Miftakhov R N, Wingate D L
Gastrointestinal Science Research Unit, Royal London Hospital Medical College, University of London, UK.
Med Eng Phys. 1995 Jan;17(1):3-10. doi: 10.1016/1350-4533(95)01003-b.
Based on the model of the adrenergic neurone proposed earlier, the dynamics of nerve-pulse transmission after treatment with inhibitors of neuronal uptake and catechol-O-methyltransferase, alpha 1-adrenoceptor antagonists, changes in the concentration of Ca2+ ions in the external medium, the action of tetrodotoxin (TTX) and repetitive stimulation, are analysed. The results of numerical simulation show that: the addition of drugs that inhibit neuronal uptake and catechol-O-methyltransferase cause the augmentation of noradrenaline action on post-synaptic structures and an increase in the amplitude of the generated inhibitory post-synaptic potential (IPSP); treatment with adrenergic antagonists reduces the amplitude of IPSP; decrease in the concentration of extracellular Ca2+ ions and application of TTX abolish the post-synaptic response. All these effects are shown to be dose-dependent. The repetitive stimulation of the neurone reproduces the effects of accumulation and potentiation. Possible applications of the results obtained are discussed.
基于先前提出的肾上腺素能神经元模型，分析了用神经元摄取抑制剂、儿茶酚 - O - 甲基转移酶抑制剂、α1 - 肾上腺素能受体拮抗剂处理后神经脉冲传递的动力学、细胞外介质中Ca2 +离子浓度的变化、河豚毒素（TTX）的作用以及重复刺激的影响。数值模拟结果表明：添加抑制神经元摄取和儿茶酚 - O - 甲基转移酶的药物会导致去甲肾上腺素对突触后结构的作用增强，以及产生的抑制性突触后电位（IPSP）幅度增加；用肾上腺素能拮抗剂处理会降低IPSP的幅度；细胞外Ca2 +离子浓度降低和应用TTX会消除突触后反应。所有这些效应均显示为剂量依赖性。对神经元的重复刺激再现了积累和增强的效应。讨论了所得结果的可能应用。
