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津巴布韦非霍奇金淋巴瘤的骨髓受累情况。

Bone marrow involvement in non-Hodgkin's lymphoma in Zimbabwe.

作者信息

Adewuyi B, Coutts A, Levy L, Klein S, Muronda C

机构信息

Department of Haematology, University of Zimbabwe, Harare.

出版信息

East Afr Med J. 1994 Dec;71(12):773-5.

PMID:7705245
Abstract

Lymph node and bone marrow trephine biopsies of seventy two consecutive cases of non-Hodgkin's lymphoma occurring among black Zimbabweans were reviewed to determine bone marrow involvement. The bone marrow was involved in 23.6% of patients but the proportion of bone marrow positive cases was highest in low grade lymphomas, though these were the least common type of lymphoma encountered. Cells infiltrating the marrow showed high degree of concordance with corresponding lymph node histology. Low grade lymphomas (CLL excluded) had a predominantly diffuse pattern of marrow involvement while intermediate and high grade lymphomas had nearly equal proportions with diffuse and focal patterns. Bone-marrow involvement did not make a significant difference to the staging of non-Hodgkin's lymphoma as most cases not involving the marrow also presented with advanced disease. Mean age of patients was negatively correlated with histological grade but was not related to bone marrow involvement. Central nervous system involvement occurred mostly in the high grade lymphomas and was proportionately distributed between bone marrow positive and negative cases. 40% of non-Hodgkin's lymphoma were associated with HIV infection but HIV-associated lymphoma surprisingly very rarely infiltrated the bone marrow.

摘要

回顾了72例连续发生在津巴布韦黑人中的非霍奇金淋巴瘤患者的淋巴结和骨髓环钻活检结果,以确定骨髓受累情况。23.6%的患者骨髓受累,但骨髓阳性病例比例在低级别淋巴瘤中最高,尽管这些是最不常见的淋巴瘤类型。浸润骨髓的细胞与相应的淋巴结组织学表现高度一致。低级别淋巴瘤(不包括慢性淋巴细胞白血病)骨髓受累主要为弥漫性模式,而中高级别淋巴瘤弥漫性和局灶性模式的比例几乎相等。骨髓受累对非霍奇金淋巴瘤的分期没有显著影响,因为大多数未累及骨髓的病例也表现为晚期疾病。患者的平均年龄与组织学分级呈负相关,但与骨髓受累无关。中枢神经系统受累主要发生在高级别淋巴瘤中,在骨髓阳性和阴性病例中分布比例相当。40%的非霍奇金淋巴瘤与HIV感染有关,但令人惊讶的是,HIV相关淋巴瘤很少浸润骨髓。

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