Okumoto M, Mori N, Miyashita N, Moriwaki K, Imai S, Haga S, Hiroishi S, Takamori Y, Esaki K
Department of Applied Bioscience, University of Osaka Prefecture, Japan.
Exp Anim. 1995 Jan;44(1):43-8. doi: 10.1538/expanim.44.43.
M.MOL-MSM (MSM) mice derived from Mus musculus molossinus progenitors showed extreme resistance to the induction of lymphomas following whole-body X-irradiation with four doses of 1.7 Gy. (BALB/cHeA x MSM) F1 mice between a high lymphoma strain, BALB/cHeA and the MSM showed a high incidence of radiation-induced lymphomas which was quite similar to that in BALB/cHeA mice, but the latent period was prolonged in the hybrids. Susceptibility in incidence was dominant over resistance in these crosses. Incidences of (BALB/cHeA x MSM)F1 hybrids irradiated with four doses of 2.5 Gy X-rays were 77% in females and 88% in males. F1 hybrids between BALB/cHeA and another resistant strain STS/A, (BALB/cHeA x STS/A) F1, also showed a high level of susceptibility, that is, lymphoma incidence was 64% in females and 63% in males. The mean latent period in the (BALB/cHeA x STS/A) F1 hybrids was similar to that in (BALB/cHeA x MSM) F1 hybrids. As all cases of tumors developed in F1 hybrids are informative concerning the detection of the loss of heterozygosity in the loci depending on the combination of two parental strains, the radiation-induced lymphomas obtained from (BALB/cHeA x MSM) F1 and (BALB/cHeA x STS/A) F1 hybrids could be useful for fine analysis of the genetic alterations involved in lymphomagenesis.
源自小家鼠祖系的M.MOL-MSM（MSM）小鼠在接受四剂1.7 Gy的全身X射线照射后，对淋巴瘤的诱导表现出极强的抗性。高淋巴瘤品系BALB/cHeA与MSM之间的（BALB/cHeA×MSM）F1小鼠，辐射诱导淋巴瘤的发生率很高，这与BALB/cHeA小鼠非常相似，但杂种的潜伏期延长。在这些杂交组合中，发病率的易感性对抗性呈显性。接受四剂2.5 Gy X射线照射的（BALB/cHeA×MSM）F1杂种的发病率，雌性为77%，雄性为88%。BALB/cHeA与另一个抗性品系STS/A之间的F1杂种（BALB/cHeA×STS/A）F1，也表现出高度的易感性，即淋巴瘤发病率雌性为64%，雄性为63%。（BALB/cHeA×STS/A）F1杂种的平均潜伏期与（BALB/cHeA×MSM）F1杂种相似。由于F1杂种中发生的所有肿瘤病例对于根据两个亲本品系的组合检测基因座杂合性的丧失都具有参考价值，因此从（BALB/cHeA×MSM）F1和（BALB/cHeA×STS/A）F1杂种获得的辐射诱导淋巴瘤可用于对淋巴瘤发生过程中涉及的基因改变进行精细分析。
