Initial arthritic lesions induced by immunization with type II collagen in Lewis rats.
作者信息
Takeshita M, Hinoue H, Furukawa O, Takata I
机构信息
Marugo Research Service, Tanabe Seiyaku Co., Ltd., Osaka, Japan.
出版信息
Exp Anim. 1995 Jan;44(1):63-6. doi: 10.1538/expanim.44.63.
PMID:7705481
Abstract
Lewis rats were immunized with an intradermal injection of type II collagen to study the time course of arthritic lesions. Serum type II collagen antibody was detected 9 days after immunization. Increased paw volume in the hind limbs was noted on day 11. Histopathologically, proliferation of synovial lining cells was observed on day 11 and typical lesions similar to those of human rheumatoid arthritis were noted on day 18.
摘要
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