Pollak E
Department of Statistics, Iowa State University, Ames 50011.
Genetics. 1995 Jan;139(1):439-44. doi: 10.1093/genetics/139.1.439.
If there is selection only for viability between zygote formation and adulthood, the frequency of a particular allele changes between these two stages of life. With complete mating this is all that happens, but if there is a positive probability that full sibs mate, there is an extra change between adulthood and the appearance of zygotes in the next generation. This occurs because there are then correlated frequencies of the alleles carried by the mates. An expression for the change in the frequency of an allele, which incorporates these two effects, is derived, and the result is found to be consistent with earlier work by the author on the probability of survival of a rare allele in a large population. The result is inconsistent with the usual expression for the change in frequency of an allele when there is partial inbreeding because that expression does not incorporate the second change in frequency within one generation.
如果仅在合子形成到成年期之间进行生存能力选择，那么特定等位基因的频率在生命的这两个阶段之间会发生变化。在完全随机交配的情况下，情况就是如此，但如果全同胞交配存在正概率，那么在成年期和下一代合子出现之间会有额外的变化。之所以会出现这种情况，是因为配偶所携带的等位基因频率存在相关性。推导出了一个包含这两种效应的等位基因频率变化表达式，结果发现与作者早期关于稀有等位基因在大群体中生存概率的研究结果一致。该结果与部分近亲繁殖时等位基因频率变化的常用表达式不一致，因为该表达式没有考虑一代内频率的第二次变化。
