Reed W C
Department of Obstetrics and Gynecology, Chico Medical Group, California 95926, USA.
Gynecol Oncol. 1995 Mar;56(3):452-5. doi: 10.1006/gyno.1995.1081.
Small cell carcinoma of the ovary is a rare and often lethal tumor, occurring primarily in young women. In as many as two-thirds of reported cases there is an associated paraneoplastic hypercalcemia, the symptoms of which are often what bring the patient to medical attention. This phenomenon also provides a convenient biochemical marker useful for follow-up. The origin of these tumors is unknown. Recent studies using flow cytometry would appear to distinguish these tumors from other ovarian tumors based on their DNA diploid histograms. These tumors have a very poor prognosis, and a proven regimen of adjuvant chemotherapy is yet to be defined. A case of a young woman with small cell carcinoma of the ovary with hypercalcemia, alive, with no evidence of recurrence 5 years after surgery followed by chemotherapy is reported.
卵巢小细胞癌是一种罕见且通常致命的肿瘤，主要发生在年轻女性中。在多达三分之二的报告病例中，存在相关的副肿瘤性高钙血症，其症状常常是促使患者就医的原因。这种现象还提供了一种方便的生化标志物，有助于随访。这些肿瘤的起源尚不清楚。最近使用流式细胞术的研究似乎基于其DNA二倍体直方图将这些肿瘤与其他卵巢肿瘤区分开来。这些肿瘤的预后非常差，且尚未确定经过验证的辅助化疗方案。本文报告了一例患有卵巢小细胞癌并伴有高钙血症的年轻女性病例，该患者术后接受化疗，5年后仍存活，无复发迹象。
