Reichard O, Glaumann H, Frydén A, Norkrans G, Schvarcz R, Sönnerborg A, Yun Z B, Weiland O
Department of Infectious Diseases, Karolinska Institute, Danderyd Hospital, Stockholm, Sweden.
Hepatology. 1995 Apr;21(4):918-22.
Fourteen patients with chronic hepatitis C who had a sustained response to a 60-week interferon alfa-2b treatment course were followed, biochemically and virologically, 2 years after treatment cessation. Biopsies were repeated in 12 of 14 for histological and virological evaluation at 2-year follow-up. All 14 patients had normal serum alanine transaminase (s-ALT) levels and were negative for hepatitis C virus (HCV) RNA in serum during treatment and at short-term follow-up 6 months post-treatment. At 2-year follow-up, 13 patients still had normal ALT levels (< 0.6 mukat/L for women; < 0.8 mukat/L for men), 1 a near normal level (0.76 mukat/L); all were HCV RNA negative in serum, and 11 of 12 also in the liver. Liver histology improved during treatment and remained stable during the 2-year follow-up. The authors conclude that most sustained responders, who have normal ALT levels and are nonviremic at short-term follow-up 6 months after interferon treatment, will continue to have a durable long-term response without relapse of the viremia.
对接受为期60周的干扰素α-2b治疗疗程且获得持续应答的14例慢性丙型肝炎患者在停药后进行了2年的生化和病毒学随访。14例中的12例在2年随访时重复进行了活检，以进行组织学和病毒学评估。所有14例患者在治疗期间及治疗后6个月短期随访时血清丙氨酸转氨酶（s-ALT）水平均正常，血清丙型肝炎病毒（HCV）RNA均为阴性。在2年随访时，13例患者的ALT水平仍正常（女性<0.6微卡/升；男性<0.8微卡/升），1例接近正常水平（0.76微卡/升）；所有患者血清HCV RNA均为阴性，12例中的11例肝脏中也为阴性。肝脏组织学在治疗期间有所改善，并在2年随访期间保持稳定。作者得出结论，大多数在干扰素治疗后6个月短期随访时ALT水平正常且无病毒血症的持续应答者，将继续有持久的长期应答，且病毒血症不会复发。
