Pieretti M, Powell D E, Gallion H H, Conway P S, Case E A, Turker M S
Department of Pathology, Markey Cancer Center, University of Kentucky Medical Center, Lexington 40536-0093, USA.
Hum Pathol. 1995 Apr;26(4):398-401. doi: 10.1016/0046-8177(95)90140-x.
Alterations of normal DNA methylation patterns have been reported in various types of human tumors. These alterations are represented by genome wide hypomethylation and by region specific hypermethylation. One commonly hypermethylated region is 17p13.3 (D17S5), the putative site of a tumor suppressor gene. In this study we report that hypermethylation at this locus occurs frequently (33%) in ovarian tumors. We reported previously that loss of chromosome 17 is a common event in serous epithelial ovarian tumors. A correlation of the methylation event and chromosome 17 loss suggests that hypermethylation at D17S5 precedes chromosome 17 loss.
在各类人类肿瘤中均有正常DNA甲基化模式改变的报道。这些改变表现为全基因组低甲基化以及区域特异性高甲基化。一个常见的高甲基化区域是17p13.3（D17S5），它是一个假定的肿瘤抑制基因位点。在本研究中，我们报道该位点的高甲基化在卵巢肿瘤中频繁发生（33%）。我们之前报道过17号染色体缺失在浆液性上皮性卵巢肿瘤中是常见事件。甲基化事件与17号染色体缺失之间的相关性表明，D17S5处的高甲基化先于17号染色体缺失。
