Bhattacharyya T K, Debnath P K
Department of Pharmacology, School of Tropical Medicine, Calcutta.
Indian J Physiol Pharmacol. 1995 Jan;39(1):86-8.
5-HT concentration in blood of 24 randomly selected pregnant women presenting with signs and symptoms of toxaemia of pregnancy were estimated and compared with 30 normal pregnant women. As such 5-HT level increases with the progress of pregnancy and in toxaemia group in comparison to normal pregnancy. A change in the degree of oedema from moderate to severe could bring a statistically significant change in blood pressure and serum 5-HT level. Increased 5-HT plays a role in toxaemia as well as in normal pregnancy and some of the toxic effects observed in toxaemia of pregnancy are due to the effects of 5-HT.
对24名随机选取的出现妊娠中毒症状和体征的孕妇血液中的5-羟色胺（5-HT）浓度进行了估算，并与30名正常孕妇进行了比较。结果显示，与正常妊娠相比，5-HT水平会随着妊娠进展而升高，在妊娠中毒组中也是如此。水肿程度从中度变为重度会使血压和血清5-HT水平产生具有统计学意义的变化。5-HT升高在妊娠中毒以及正常妊娠中均起作用，妊娠中毒中观察到的一些毒性作用是由5-HT的作用所致。
