Kowalski C J, Schneiderman E D, Willis S M
Department of Biologic and Materials Sciences, Dental School, University of Michigan, Ann Arbor 48109.
Int J Biomed Comput. 1994 Oct;37(2):83-91. doi: 10.1016/0020-7101(94)90131-7.
A method for separating the effects of a treatment from those of normal development in the case of a randomized parallel groups design with pre- and post-treatment measures is described and implemented. The program allows the user to enter either summary statistics (published data are often in this form), or the pre- and post-treatment measurements for each individual. The program is illustrated using data reflecting the extent to which a treatment can be expected to impede normal growth, but the method and program are more general than this. All that is required is that the measurement be one that normally increases over time.
