酒精性肝硬化戒酒和未戒酒患者的蛋白质周转情况。
Protein turnover in abstinent and non-abstinent patients with alcoholic cirrhosis.
作者信息
Hirsch S, de la Maza M P, Petermann M, Iturriaga H, Ugarte G, Bunout D
机构信息
Institute of Nutrition and Food Technology, San Borja Arriarán Hospital.
出版信息
J Am Coll Nutr. 1995 Feb;14(1):99-104. doi: 10.1080/07315724.1995.10718479.
OBJECTIVE
This study was designed to measure the effect of chronic alcohol intake on leucine turnover in outpatients with stable alcoholic liver cirrhosis.
METHODS
Protein turnover rate was measured using L [1-14C] leucine in ten outpatients with proven alcoholic cirrhosis and in five healthy controls. After the performance of the turnover, the patients were divided in two groups depending on the evidence of alcohol ingestion in the previous month.
RESULTS
Non-abstinent patients had a significantly higher leucine flux and non-oxidative disposal (73.8 +/- 25.4 and 65.9 +/- 21.6) than abstinent cirrhotic patients (48.9 +/- 9.5 and 43.7 +/- 9.0) and normal controls 37.3 +/- 8.9 and 31.1 +/- 7.6 mumol/m2/min (p < 0.01). Leucine oxidation and serum leucine levels were similar in the three groups.
CONCLUSION
Alcohol intake in alcoholic cirrhotic patients has a catabolic effect that could be associated with the nutritional imbalances observed in alcoholic liver disease.
目的
本研究旨在测定长期饮酒对稳定期酒精性肝硬化门诊患者亮氨酸代谢率的影响。
方法
采用L-[1-14C]亮氨酸测定了10例确诊为酒精性肝硬化的门诊患者和5例健康对照者的蛋白质代谢率。在完成代谢率测定后，根据患者前一个月的饮酒情况将其分为两组。
结果
未戒酒的患者亮氨酸通量和非氧化代谢率（分别为73.8±25.4和65.9±21.6）显著高于戒酒的肝硬化患者（分别为48.9±9.5和43.7±9.0）以及正常对照组（分别为37.3±8.9和31.1±7.6μmol/m2/min，p<0.01）。三组患者的亮氨酸氧化率和血清亮氨酸水平相似。
结论
酒精性肝硬化患者饮酒具有分解代谢作用，这可能与酒精性肝病中观察到的营养失衡有关。
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