Skov K, Nyengaard J R, Korsgaard N, Mulvany M J
Department of Pathology, Aarhus University Hospital, Denmark.
J Hypertens. 1994 Dec;12(12):1373-6.
A reduced number of nephrons, whether acquired or congenital, as has been observed in certain inbred rat strains, may lead to systemic hypertension. The present study estimated the total number of glomeruli and mean glomerular size in kidneys of spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats.
Unbiased stereological methods were used on immersion-fixed kidneys from 12-week-old male SHR (n = 9) and age-matched WKY rats (n = 11).
The total number of glomeruli was significantly reduced in the SHR compared with in the WKY rats. Sclerotic glomeruli were not found in either group. No significant difference in mean glomerular volume was observed, but the total glomerular volume was reduced by 25% in the SHR compared with in the WKY rats.
SHR have fewer glomeruli than WKY rats, but of similar size, resulting in a reduced total glomerular volume in adult SHR. These findings are consistent with the hypothesis that the kidney plays an important role in the pathogenesis of genetic hypertension.
如在某些近交系大鼠品系中所观察到的，无论是后天获得还是先天性的肾单位数量减少，都可能导致全身性高血压。本研究估算了自发性高血压大鼠（SHR）和血压正常的Wistar-Kyoto（WKY）大鼠肾脏中肾小球的总数和平均肾小球大小。
对12周龄雄性SHR（n = 9）和年龄匹配的WKY大鼠（n = 11）的浸液固定肾脏采用无偏倚体视学方法。
与WKY大鼠相比，SHR的肾小球总数显著减少。两组均未发现硬化性肾小球。平均肾小球体积未观察到显著差异，但与WKY大鼠相比，SHR的总肾小球体积减少了25%。
SHR的肾小球数量比WKY大鼠少，但大小相似，导致成年SHR的总肾小球体积减小。这些发现与肾脏在遗传性高血压发病机制中起重要作用的假说一致。
