Natanson S, Sela S, Moses A E, Musser J M, Caparon M G, Hanski E
Department of Clinical Microbiology and Infectious Diseases, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
J Infect Dis. 1995 Apr;171(4):871-8. doi: 10.1093/infdis/171.4.871.
Binding of fibronectin by group A streptococci (GAS) promotes adherence to epithelial cells. The fibronectin-binding activity and the presence of prtF, a gene encoding a fibronectin-binding protein, were studied among 109 strains. Fifty-six strains of 42 different M types possessed prtF-related genes, and 89% of these strains bound fibronectin at high levels. The prtF-related genes varied in the number of repeats that constitute one of its two fibronectin-binding domains. Fifty-three strains of 21 different M types lacked prtF. Thirty-nine of these (74%), representing 13 different M types, bound fibronectin at very low levels. However, 9 (17%), of 5 different M types, bound fibronectin at high levels. The presence of prtF and the capacity to bind fibronectin correlated strongly with the M type of various strains of GAS. This correlation may suggest the existence of a relationship between fibronectin binding and the pathogenic potential of GAS.
A组链球菌（GAS）与纤连蛋白的结合促进其对上皮细胞的黏附。对109株菌株研究了纤连蛋白结合活性及编码纤连蛋白结合蛋白的基因prtF的存在情况。42种不同M型的56株菌株拥有prtF相关基因，其中89%的菌株能高水平结合纤连蛋白。构成其两个纤连蛋白结合结构域之一的重复序列数量在prtF相关基因中有所不同。21种不同M型的53株菌株缺乏prtF。其中39株（74%），代表13种不同M型，只能极低水平结合纤连蛋白。然而，5种不同M型中的9株（17%）能高水平结合纤连蛋白。prtF的存在及结合纤连蛋白的能力与不同GAS菌株的M型密切相关。这种相关性可能表明纤连蛋白结合与GAS致病潜力之间存在某种关系。
