Yoshida Y, Seto T, Ohsu W, Hayashi S, Okazawa T, Nagase H, Yoshida M, Nakamura H
Department of Public Health, Kanazawa University School of Medicine.
Nihon Sanka Fujinka Gakkai Zasshi. 1995 Feb;47(2):101-8.
Effects of microwaves on fetus and female genital organs remain to be elucidated. To demonstrate the placental circulatory disturbances induced by microwaves and to clarify the endocrine pathogenesis, placental blood flow and five endocrine indicators, i.e., corticosterone (CS), estradiol (E2), progesterone (P), prostaglandin E2 (PGE2) and prostaglandin F2 alpha (PGF2 alpha) were measured in rats exposed to whole-body microwaves with an intensity of 10 mW/cm2 at a frequency of 2,450 MHz. The placental blood flow at 45-90 min after exposure was significantly decreased in the rats exposed to the microwaves. Placental blood flow at 15 and 30 min was increased by pretreatment with intraperitoneal administration of angiotensin II (AII). In contrast, no significant change in placental blood flow was recognized in the AII pretreated rats exposed to the microwaves. An increase in CS and a decrease in E2 were induced by the microwave exposure independent of pretreatment with AII. P was increased by microwave exposure in the rats without pretreatment with AII. PGE2 was not changed by the microwave exposure in the case of either nonpretreatment or pretreatment with AII. PGF2 alpha was increased by the microwave exposure in the rats without pretreatment with AII. The present results indicate that excessive exposure to whole-body microwave disorders pregnancy in terms of placental circulatory dysfunction. The data suggest the involvement of endocrine mechanisms in the decrease in placental blood flow which is induced via a detrimental effect of microwaves on PGF2 alpha and on pituitary functions such as general emotional stress.
微波对胎儿和女性生殖器官的影响仍有待阐明。为了证明微波引起的胎盘循环紊乱并阐明内分泌发病机制，对暴露于频率为2450 MHz、强度为10 mW/cm² 的全身微波的大鼠测量了胎盘血流量和五项内分泌指标，即皮质酮（CS）、雌二醇（E2）、孕酮（P）、前列腺素E2（PGE2）和前列腺素F2α（PGF2α）。暴露后45 - 90分钟，暴露于微波的大鼠胎盘血流量显著降低。腹腔注射血管紧张素II（AII）预处理可使15和30分钟时的胎盘血流量增加。相反，在暴露于微波的AII预处理大鼠中，未观察到胎盘血流量有显著变化。无论是否用AII预处理，微波暴露均可导致CS升高和E2降低。在未用AII预处理的大鼠中，微波暴露可使P升高。无论是否进行预处理，微波暴露均未改变PGE2水平。在未用AII预处理的大鼠中，微波暴露可使PGF2α升高。目前的结果表明，全身微波过度暴露会导致胎盘循环功能障碍，从而影响妊娠。数据表明，内分泌机制参与了胎盘血流量的减少，这是通过微波对PGF2α和垂体功能（如一般情绪应激）的有害作用诱导的。
