Antony F F, Aruldhas M M, Udhayakumar R C, Maran R R, Govindarajulu P
Department of Endocrinology, University of Madras, Taramani, India.
J Endocrinol. 1995 Feb;144(2):293-300. doi: 10.1677/joe.0.1440293.
Leydig cell steroidogenic activity under basal and stimulated conditions was studied in hypothyroid rats. Hypothyroidism was induced at a prepubertal age (30 days postpartum) by surgical thyroidectomy, and L-thyroxine (T4) supplementation (6 micrograms/100 g body weight/day for 30 days) to hypothyroid rats was begun after 30 days. Hypothyroidism for 60 days reduced serum LH and FSH without affecting prolactin. Serum and intratesticular testosterone and the specific activity of Leydig cell 3 beta- and 17 beta-hydroxysteroid dehydrogenases diminished in hypothyroid rats. The stimulatory effect of LH on Leydig cell steroidogenic activity and cAMP was also adversely affected in hypothyroid rats. All these changes were reversed by T4 supplementation. The present results suggest that prepubertal hypothyroidism suppresses both basal and stimulated Leydig cell activity in adult rats.
在甲状腺功能减退的大鼠中研究了基础状态和刺激状态下睾丸间质细胞的类固醇生成活性。在青春期前（产后30天）通过手术切除甲状腺诱导甲状腺功能减退，30天后开始对甲状腺功能减退的大鼠补充L-甲状腺素（T4）（6微克/100克体重/天，持续30天）。甲状腺功能减退60天可降低血清促黄体生成素（LH）和促卵泡生成素（FSH），而不影响催乳素。甲状腺功能减退的大鼠血清和睾丸内睾酮以及睾丸间质细胞3β-和17β-羟基类固醇脱氢酶的比活性降低。LH对睾丸间质细胞类固醇生成活性和环磷酸腺苷（cAMP）的刺激作用在甲状腺功能减退的大鼠中也受到不利影响。补充T4可逆转所有这些变化。目前的结果表明，青春期前甲状腺功能减退会抑制成年大鼠基础状态和刺激状态下的睾丸间质细胞活性。
