慢性中性粒细胞白血病——病例报告

Chronic neutrophilic leukemia--a case report.

作者信息

Chang C S, Lin S F, Hwang S M, Liu T C, Chen T P, Chiang W

机构信息

Division of Hemato-oncology, Kaohsiung Medical College, Taiwan, Republic of China.

出版信息

Gaoxiong Yi Xue Ke Xue Za Zhi. 1995 Mar;11(3):181-5.

PMID:7707468

Abstract

We describe a 77-year-old patient with chronic neutrophilic leukemia (CNL). Diagnosis of CNL was made by marked increase of mature neutrophils without increased immature granulocytes, splenomegaly and elevated serum vitamin B12 level and by ruling out any infection or occult malignancy. The chromosome analysis showed one abnormal karyotype out of 14 metaphases. The neutrophilic function with nitroblue tetrazolium test revealed impaired phagocytic function in this patient. The neutrophil count became normal gradually after hydroxyurea treatment. However, it still maintained a high percentage of mature neutrophils. Background literature and the prognosis of CNL are discussed.

摘要

我们描述了一名患有慢性中性粒细胞白血病（CNL）的77岁患者。CNL的诊断依据是成熟中性粒细胞显著增多，未成熟粒细胞无增多，脾肿大，血清维生素B12水平升高，且排除了任何感染或隐匿性恶性肿瘤。染色体分析显示，14个中期相中出现1个异常核型。硝基蓝四氮唑试验检测的中性粒细胞功能显示该患者吞噬功能受损。羟基脲治疗后中性粒细胞计数逐渐恢复正常。然而，成熟中性粒细胞仍维持在较高比例。文中还讨论了相关背景文献及CNL的预后情况。