• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Bovine papillomavirus E1 protein can, by itself, efficiently drive multiple rounds of DNA synthesis in vitro.牛乳头瘤病毒E1蛋白自身就能在体外有效地驱动多轮DNA合成。
J Virol. 1995 May;69(5):3201-5. doi: 10.1128/JVI.69.5.3201-3205.1995.
2
Bovine papillomavirus type 1 DNA replication: the transcriptional activator E2 acts in vitro as a specificity factor.牛乳头瘤病毒1型DNA复制：转录激活因子E2在体外作为特异性因子发挥作用。
J Virol. 1997 Sep;71(9):6805-15. doi: 10.1128/JVI.71.9.6805-6815.1997.
3
Co-operative interaction between the initiator E1 and the transcriptional activator E2 is required for replicator specific DNA replication of bovine papillomavirus in vivo and in vitro.引发因子E1与转录激活因子E2之间的协同相互作用是牛乳头瘤病毒在体内和体外进行复制子特异性DNA复制所必需的。
EMBO J. 1995 Dec 15;14(24):6218-28. doi: 10.1002/j.1460-2075.1995.tb00312.x.
4
Modulation of bovine papillomavirus DNA replication by phosphorylation of the viral E1 protein.通过病毒E1蛋白磷酸化对牛乳头瘤病毒DNA复制的调控
Virology. 1997 Feb 3;228(1):1-10. doi: 10.1006/viro.1996.8375.
5
Bovine papilloma virus (BPV)-encoded E2 protein enhances binding of E1 protein to the BPV replication origin.牛乳头瘤病毒（BPV）编码的E2蛋白增强E1蛋白与BPV复制起点的结合。
Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):2865-9. doi: 10.1073/pnas.90.7.2865.
6
Amino acids critical for the functions of the bovine papillomavirus type 1 E2 transactivator.对牛乳头瘤病毒1型E2反式激活因子功能至关重要的氨基酸。
J Virol. 1996 Jan;70(1):23-9. doi: 10.1128/JVI.70.1.23-29.1996.
7
Competition for DNA binding sites between the short and long forms of E2 dimers underlies repression in bovine papillomavirus type 1 DNA replication control.1型牛乳头瘤病毒DNA复制控制中的抑制作用源于E2二聚体短形式和长形式之间对DNA结合位点的竞争。
J Virol. 1998 Mar;72(3):1931-40. doi: 10.1128/JVI.72.3.1931-1940.1998.
8
Characterization of the DNA-binding domain of the bovine papillomavirus replication initiator E1.牛乳头瘤病毒复制起始因子E1的DNA结合结构域的特性分析
J Virol. 1998 Apr;72(4):2567-76. doi: 10.1128/JVI.72.4.2567-2576.1998.
9
Topography of bovine papillomavirus E2 protein on the viral genome during the cell cycle.细胞周期中牛乳头瘤病毒E2蛋白在病毒基因组上的定位
Virology. 2009 Oct 25;393(2):258-64. doi: 10.1016/j.virol.2009.07.037. Epub 2009 Aug 28.
10
Binding of the E1 and E2 proteins to the origin of replication of bovine papillomavirus.E1和E2蛋白与牛乳头瘤病毒复制起点的结合。
J Virol. 1997 Apr;71(4):2887-96. doi: 10.1128/JVI.71.4.2887-2896.1997.

引用本文的文献

1
Ring-shaped replicative helicase encircles double-stranded DNA during unwinding.环形复制解旋酶在解开双链 DNA 时环绕双链 DNA。
Nucleic Acids Res. 2019 Dec 2;47(21):11344-11354. doi: 10.1093/nar/gkz893.
2
The E1 proteins.E1 蛋白。
Virology. 2013 Oct;445(1-2):35-56. doi: 10.1016/j.virol.2013.07.020. Epub 2013 Sep 10.
3
Genomic instability of the host cell induced by the human papillomavirus replication machinery.人乳头瘤病毒复制机制诱导的宿主细胞基因组不稳定性。
EMBO J. 2007 Apr 18;26(8):2180-91. doi: 10.1038/sj.emboj.7601665. Epub 2007 Mar 29.
4
Nucleocytoplasmic shuttling of bovine papillomavirus E1 helicase downregulates viral DNA replication in S phase.牛乳头瘤病毒E1解旋酶的核质穿梭在S期下调病毒DNA复制。
J Virol. 2007 Jan;81(1):384-94. doi: 10.1128/JVI.01170-06. Epub 2006 Oct 11.
5
Proteins of the PIAS family enhance the sumoylation of the papillomavirus E1 protein.PIAS家族的蛋白质增强乳头瘤病毒E1蛋白的类泛素化修饰。
Virology. 2005 Jan 5;331(1):190-203. doi: 10.1016/j.virol.2004.10.025.
6
Bovine papillomavirus replicative helicase E1 is a target of the ubiquitin ligase APC.牛乳头瘤病毒复制解旋酶E1是泛素连接酶APC的一个靶点。
J Virol. 2004 Mar;78(5):2615-9. doi: 10.1128/jvi.78.5.2615-2619.2004.
7
Regulation of bovine papillomavirus replicative helicase e1 by the ubiquitin-proteasome pathway.泛素-蛋白酶体途径对牛乳头瘤病毒复制解旋酶E1的调控
J Virol. 2002 Nov;76(22):11350-8. doi: 10.1128/jvi.76.22.11350-11358.2002.
8
Papillomavirus E1 proteins: form, function, and features.乳头瘤病毒E1蛋白：形态、功能及特征
Virus Genes. 2002 Jun;24(3):275-90. doi: 10.1023/a:1015336817836.
9
Induction of the bovine papillomavirus origin "onion skin"-type DNA replication at high E1 protein concentrations in vivo.在体内高浓度E1蛋白条件下诱导牛乳头瘤病毒起始位点的“洋葱皮”型DNA复制。
J Virol. 2002 Jun;76(11):5835-45. doi: 10.1128/jvi.76.11.5835-5845.2002.
10
Identification of a short, hydrophilic amino acid sequence critical for origin recognition by the bovine papillomavirus E1 protein.鉴定对牛乳头瘤病毒E1蛋白识别起始位点至关重要的一段短亲水性氨基酸序列。
J Virol. 2000 Jan;74(1):245-53. doi: 10.1128/jvi.74.1.245-253.2000.

本文引用的文献

1
How transcription factors regulate origins of DNA replication in eukaryotic cells.转录因子如何调控真核细胞中DNA复制的起始位点。
Trends Cell Biol. 1993 May;3(5):161-7. doi: 10.1016/0962-8924(93)90137-p.
2
The acidic transcriptional activation domains of VP16 and p53 bind the cellular replication protein A and stimulate in vitro BPV-1 DNA replication.VP16和p53的酸性转录激活结构域与细胞复制蛋白A结合，并在体外刺激牛乳头瘤病毒1型（BPV-1）DNA复制。
Cell. 1993 Jun 18;73(6):1207-21. doi: 10.1016/0092-8674(93)90649-b.
3
The E1 protein of bovine papilloma virus 1 is an ATP-dependent DNA helicase.牛乳头瘤病毒1的E1蛋白是一种依赖ATP的DNA解旋酶。
Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):5086-90. doi: 10.1073/pnas.90.11.5086.
4
Bovine papilloma virus (BPV)-encoded E2 protein enhances binding of E1 protein to the BPV replication origin.牛乳头瘤病毒（BPV）编码的E2蛋白增强E1蛋白与BPV复制起点的结合。
Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):2865-9. doi: 10.1073/pnas.90.7.2865.
5
Binding of bovine papillomavirus E1 to the origin is not sufficient for DNA replication.牛乳头瘤病毒E1与起始点的结合不足以进行DNA复制。
Virology. 1993 Mar;193(1):201-12. doi: 10.1006/viro.1993.1116.
6
The bovine papillomavirus origin of replication requires a binding site for the E2 transcriptional activator.牛乳头瘤病毒复制起点需要E2转录激活因子的结合位点。
Proc Natl Acad Sci U S A. 1993 Feb 1;90(3):898-902. doi: 10.1073/pnas.90.3.898.
7
Bovine papilloma virus (BPV)-encoded E1 protein contains multiple activities required for BPV DNA replication.牛乳头瘤病毒（BPV）编码的E1蛋白含有BPV DNA复制所需的多种活性。
Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):702-6. doi: 10.1073/pnas.90.2.702.
8
DNA binding specificity of the bovine papillomavirus E1 protein is determined by sequences contained within an 18-base-pair inverted repeat element at the origin of replication.牛乳头瘤病毒E1蛋白的DNA结合特异性由复制起点处一个18碱基对反向重复元件内所含的序列决定。
J Virol. 1994 Feb;68(2):1094-102. doi: 10.1128/JVI.68.2.1094-1102.1994.
9
Acidic transcription factors alleviate nucleosome-mediated repression of DNA replication of bovine papillomavirus type 1.酸性转录因子减轻核小体介导的1型牛乳头瘤病毒DNA复制抑制。
Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):7051-5. doi: 10.1073/pnas.91.15.7051.
10
Replication of bovine papillomavirus type 1 origin-containing DNA in crude extracts and with purified proteins.含有1型牛乳头瘤病毒起源的DNA在粗提物中以及与纯化蛋白一起的复制。
J Biol Chem. 1994 Jun 24;269(25):17086-94.

牛乳头瘤病毒E1蛋白自身就能在体外有效地驱动多轮DNA合成。

Bovine papillomavirus E1 protein can, by itself, efficiently drive multiple rounds of DNA synthesis in vitro.

作者信息

Bonne-Andrea C, Santucci S, Clertant P

机构信息

Centre de Biochimie, Unité 273 de l'Institut National de la Santé et de la Recherche Médicale, Nice, France.

出版信息

J Virol. 1995 May;69(5):3201-5. doi: 10.1128/JVI.69.5.3201-3205.1995.

DOI:10.1128/JVI.69.5.3201-3205.1995
PMID:7707551
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC189025/
Abstract

Bovine papillomavirus E1 protein was found to be as efficient as the simian virus 40 large T antigen in initiating DNA synthesis in a cell-free system derived from COS1 cells. Multiple rounds of DNA synthesis occur, initiated at the bovine papillomavirus type 1 origin. Therefore, E1 functions in vitro as a lytic virus initiator.

摘要

研究发现，在源自COS1细胞的无细胞体系中，牛乳头瘤病毒E1蛋白在启动DNA合成方面与猿猴病毒40大T抗原一样高效。以1型牛乳头瘤病毒的起始位点开始，会发生多轮DNA合成。因此，E1在体外作为一种裂解病毒起始因子发挥作用。