Cooper A J
St. Thomas Psychiatric Hospital, Ontario, Canada.
Ment Retard. 1995 Feb;33(1):42-8.
A minority of individuals with mental retardation engage in offensive sexual behavior (e.g., child molestation, genital exposure, rape). Many of these individuals may benefit from the adjunctive administration of antilibidinal drugs. The two most widely used are the antiandrogens, medroxyprogesterone acetate (MPA) and cyproterone acetate (CPA). In the present paper the efficacy, cautions, side effects, and mode(s) of action of these substances were reviewed and medico-legal issues surrounding their use discussed. Controlled studies of antilibidinal agents with adequate numbers of patients using clearly defined (e.g., cognitive abilities) and valid and reliable outcome measures are needed.
少数智力迟钝者会出现攻击性的性行为（如猥亵儿童、暴露生殖器、强奸）。这些人中的许多人可能会从抗性欲药物的辅助治疗中获益。两种使用最广泛的药物是抗雄激素类药物，醋酸甲羟孕酮（MPA）和醋酸环丙孕酮（CPA）。本文回顾了这些药物的疗效、注意事项、副作用和作用方式，并讨论了围绕其使用的医学法律问题。需要进行对照研究，纳入足够数量的患者，使用明确界定的（如认知能力）、有效且可靠的结果测量指标来研究抗性欲药物。
