Morishima Y, Tashiro T, Takagi K, Yamamori H, Mashima Y, Nakajima N, Ito I
First Department of Surgery, Chiba University Medical School, Japan.
Nihon Geka Gakkai Zasshi. 1995 Feb;96(2):72-9.
Effect of insulin-like growth factor-I (IGF-I) on protein metabolism was investigated in burned rats receiving TPN. Twenty-six male SD rats were divided into two groups. IGF-I was administered to group IGF (IGF-I group, n = 14), but not to group C (Control group, n = 12). Loss of body weight after burn in group IGF was significantly lower than group C (p < 0.01). Cumulative nitrogen balance for 2 postburn days in group IGF was significantly higher than group C (p < 0.01). Rate of whole body protein turnover, synthesis and breakdown increased significantly in group IGF compared with group C. On the other hand, blood glucose was decreased significantly in group IGF (p < 0.05). Water balance made no significant difference between two groups. In group IGF, weight of the spleen, kidney, small intestine and colon increased significantly. Fractional synthesis rate and protein content of mucosa of the small intestine were significantly higher in group IGF than group C. From the histological point of view, mucosal layer was thickened and hyperplastic. Catabolism and surgical diabetes are caused in the surgical stress, and the administration of IGF-I are thought to be effective for improvement of those conditions. And IGF-I has the most remarkable effect on the small intestine of all organs studied in our experiment.
研究了胰岛素样生长因子-I（IGF-I）对接受全胃肠外营养（TPN）的烧伤大鼠蛋白质代谢的影响。26只雄性SD大鼠分为两组。IGF组（IGF-I组，n = 14）给予IGF-I，而C组（对照组，n = 12）不给予。IGF组烧伤后体重减轻明显低于C组（p < 0.01）。IGF组烧伤后2天的累积氮平衡明显高于C组（p < 0.01）。与C组相比，IGF组全身蛋白质周转、合成和分解速率显著增加。另一方面，IGF组血糖显著降低（p < 0.05）。两组之间水平衡无显著差异。IGF组脾脏、肾脏、小肠和结肠重量显著增加。IGF组小肠黏膜的分数合成率和蛋白质含量显著高于C组。从组织学角度看，黏膜层增厚且增生。手术应激会导致分解代谢和外科糖尿病，而给予IGF-I被认为对改善这些情况有效。并且在我们实验研究的所有器官中，IGF-I对小肠的作用最为显著。
