Hayakawa H, Okamoto Y, Shimizu M, Nishida A, Motohashi N, Yamawaki S
Department of Psychiatry and Neurosciences, Hiroshima University School of Medicine, Japan.
Neuropsychobiology. 1995;31(1):1-5. doi: 10.1159/000119164.
The effects of a single or repeated treatment with electroconvulsive shock (ECS) or imipramine on the central serotonin (5-HT) uptake binding sites were studied in the rat frontal cortex and hippocampus. The selective 5-HT uptake inhibitor citalopram and clomipramine potently inhibited the binding for [3H]paroxetine (5-HT uptake binding sites) in the frontal cortex. The antidepressant drugs imipramine and desipramine inhibited the binding moderately, but the 5-HT-related agents, 5-HT, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), mianserin and ketanserin inhibited it weakly. A single ECS increased the density of [3H]paroxetine binding sites, but did not alter the affinity, after 1 or 24 h, in the frontal cortex. Repeated treatment with ECS, but not with imipramine, increased the density of [3H]paroxetine binding sites in the same region. The hippocampal [3H]paroxetine binding did not change after any of these treatments. These results suggest that a single treatment with ECS causes a rapid increase in the neuronal 5-HT transporter complex and the increase lasts for 14 days in the frontal cortex.
研究了电惊厥休克（ECS）或丙咪嗪单次或重复治疗对大鼠额叶皮质和海马中5-羟色胺（5-HT）摄取结合位点的影响。选择性5-HT摄取抑制剂西酞普兰和氯米帕明可有效抑制额叶皮质中[3H]帕罗西汀（5-HT摄取结合位点）的结合。抗抑郁药丙咪嗪和地昔帕明对结合有中度抑制作用，但5-HT相关药物5-HT、8-羟基-2-（二正丙基氨基）四氢萘（8-OH-DPAT）、米安色林和酮色林对其抑制作用较弱。单次ECS治疗在1小时或24小时后可增加额叶皮质中[3H]帕罗西汀结合位点的密度，但不改变其亲和力。重复ECS治疗而非丙咪嗪治疗可增加同一区域中[3H]帕罗西汀结合位点的密度。这些治疗后海马中[3H]帕罗西汀结合无变化。这些结果表明，单次ECS治疗可使神经元5-HT转运体复合物迅速增加，且这种增加在额叶皮质中持续14天。
