Lensing P, Schimke H, Klimesch W, Pap V, Szemes G, Klingler D, Panksepp J
Department of Physiological Psychology, University of Salzburg, Austria.
Neuropsychobiology. 1995;31(1):16-23. doi: 10.1159/000119167.
Event-related desynchronization and visual orientational behavior were examined in 2 autistic boys to determine if blockade of endogenous opioid activity facilitates cognitive processing at a cortical level. Before naltrexone, the boys showed no selective alpha blocking during exposure to either mother's pictures or white light. Unlike normals, they exhibited strong alpha band enhancement at temporocentral recording sites. Two hours after administering 0.5 mg/kg naltrexone, mother-as well as light-related alpha blocking appeared at occipital, occipitotemporal, and prefrontal sites. These effects were gone 24 h after dosing in one child, but persisted in the other. A parallel increase in visual pursuit in a social context was observed. These results affirm that autistic gaze aversion can be caused by excessive opioid activity interfering with corticothalamocortical processing of visual stimuli.
对2名自闭症男孩的事件相关去同步化和视觉定向行为进行了检查，以确定内源性阿片类活性的阻断是否有助于皮质水平的认知加工。在使用纳曲酮之前，男孩们在观看母亲的照片或白光时均未表现出选择性α波阻断。与正常人不同，他们在颞中央记录部位表现出强烈的α波增强。在给予0.5mg/kg纳曲酮两小时后，枕叶、枕颞叶和前额叶部位出现了与母亲以及光相关的α波阻断。这些效应在一名儿童给药24小时后消失，但在另一名儿童中持续存在。在社交情境中观察到视觉追踪同时增加。这些结果证实，自闭症患者的目光回避可能是由于过量的阿片类活性干扰了视觉刺激的皮质-丘脑-皮质加工。
