Rubilar M, Brochwicz-Lewinski M J, Anderson M, Leitch A G
Royal Victoria Chest Clinic, Chalmers Hospital, Edinburgh, U.K.
Respir Med. 1995 Feb;89(2):113-20. doi: 10.1016/0954-6111(95)90193-0.
We have reviewed the records of 632 (80%) of the 788 index cases of tuberculosis notified in Edinburgh from 1982-1991 to assess the value of contact procedures for tuberculosis. Screening was by tuberculin testing and radiological follow-up for 6 months. Fifty (7.9%) of 632 notifications were detected by contact procedures and a further 35 contacts had recent infection qualifying for chemoprophylaxis. Tuberculosis was diagnosed at the first clinic visit in 38 (76%) cases and a further 11 (22%) were diagnosed at 3 months. Twenty-seven (54%) contacts with tuberculosis were in the 0-14 year age group. BCG vaccination offered 59% protection. Forty-two (84%) cases of tuberculosis were in contacts of sputum smear-positive respiratory index cases. Contact procedures continue to be effective in identifying new cases of tuberculosis in Edinburgh. Most cases occur in children who are close contacts of smear-positive respiratory index cases and are identified within 3 months of initiating screening. Screening of close contacts other than those of smear-positive respiratory disease is usually unnecessary.
我们回顾了1982年至1991年在爱丁堡通报的788例结核病索引病例中的632例(80%)记录,以评估结核病接触者追踪程序的价值。筛查方法为结核菌素试验及6个月的影像学随访。632例通报病例中,有50例(7.9%)是通过接触者追踪程序发现的,另有35名接触者近期感染,符合化学预防条件。38例(76%)在首次门诊就诊时被诊断为结核病,另有11例(22%)在3个月时被诊断。27例(54%)患结核病的接触者年龄在0至14岁组。卡介苗接种提供了59%的保护率。42例(84%)结核病病例是痰涂片阳性呼吸道索引病例的接触者。在爱丁堡,接触者追踪程序在发现结核病新病例方面仍然有效。大多数病例发生在痰涂片阳性呼吸道索引病例的密切接触儿童中,且在开始筛查的3个月内被发现。除痰涂片阳性呼吸道疾病接触者外,通常无需对密切接触者进行筛查。