Ormerod L P
Chest Clinic, Blackburn, Lancs, U.K.
Respir Med. 1993 Feb;87(2):127-31. doi: 10.1016/0954-6111(93)90140-u.
Between 1982 and 1990, 649 index cases of tuberculosis were seen of which 429 (66.1%) were of Indian Subcontinent (ISC) ethnic origin: 7017 close contacts of these cases were screened, 50 cases of tuberculosis were detected (7.7% of notifications) and 372 children given chemoprophylaxis. All cases of tuberculosis detected in the white ethnic group were contacts of smear-positive pulmonary disease, six (46%) found at initial screening, five (38%) at 1 year and one (8%) at 2 year follow-up. Of 37 cases detected in the ISC ethnic group, only 14 (38%) were contacts of smear-positive disease, 17 (46%) being contacts of other respiratory disease, and six (16%) contacts of non-respiratory disease. Eighteen (49%) of ISC cases detected were at initial screening, with six (16%), eight (22%) and three (8%), respectively, at 6 month, 1 year and 2 year follow-up. The results support the revised Joint Tuberculosis Committee advice on contact tracing, with differential contact programmes depending on type of disease and ethnic group of index cases.
1982年至1990年间,共诊治了649例结核病索引病例,其中429例(66.1%)为印度次大陆(ISC)族裔:对这些病例的7017名密切接触者进行了筛查,检测出50例结核病(占通报病例的7.7%),并对372名儿童进行了化学预防。在白种人族群中检测出的所有结核病病例均为涂片阳性肺结核病的接触者,6例(46%)在初次筛查时发现,5例(38%)在1年随访时发现,1例(8%)在2年随访时发现。在ISC族裔中检测出的37例病例中,只有14例(38%)是涂片阳性疾病的接触者,17例(46%)是其他呼吸道疾病的接触者,6例(16%)是非呼吸道疾病的接触者。在检测出的ISC病例中,18例(49%)在初次筛查时发现,6个月、1年和2年随访时分别有6例(16%)、8例(22%)和3例(8%)。结果支持联合结核病委员会修订后的关于接触者追踪的建议,即根据疾病类型和索引病例的族裔群体制定不同的接触者计划。