Lassen K O, Hørder M
Department of Clinical Chemistry, University Hospital, Odense, Denmark.
Scand J Clin Lab Invest. 1994 Dec;54(8):585-90. doi: 10.3109/00365519409087535.
The selenium status of 57 elderly people (> or = 65 years) has been investigated on the basis of selenium concentration in serum, whole blood and erythrocytes and on the basis of the activity of the selenium-dependent enzyme glutathione peroxidase (GSH-px) in erythrocytes and plasma. Thirty-six elderly subjects participated in a 4-month trial of supplementation: 12 subjects were supplemented with 125 micrograms organic selenium, 12 subjects were supplemented with 125 micrograms inorganic selenium and 12 subjects participated as controls. The results showed that the selenium status of the elderly people was not significantly lower than that of younger people (p > 0.05). The effect of organic and inorganic selenium on the activity of GSH-px in plasma and erythrocytes showed a nearly identical increase (25-35%) during the period of supplementation. The effect of inorganic selenium supplementation caused a 30% increase in selenium concentration in plasma and erythrocytes which stabilized after 4 weeks. The effect of organic selenium supplementation on selenium concentration in plasma and erythrocytes showed an increase of up to 100% and 120% during the period of supplementation.
基于血清、全血和红细胞中的硒浓度，以及红细胞和血浆中硒依赖性酶谷胱甘肽过氧化物酶（GSH-px）的活性，对57名老年人（≥65岁）的硒状况进行了调查。36名老年受试者参与了为期4个月的补充试验：12名受试者补充125微克有机硒，12名受试者补充125微克无机硒，12名受试者作为对照。结果表明，老年人的硒状况并不显著低于年轻人（p>0.05）。在补充期间，有机硒和无机硒对血浆和红细胞中GSH-px活性的影响显示出几乎相同的增加（25%-35%）。补充无机硒使血浆和红细胞中的硒浓度增加了30%，4周后趋于稳定。补充有机硒对血浆和红细胞中硒浓度的影响在补充期间分别增加了高达100%和120%。
