Galetto-Lacour A, Kinloch-de Loës S, Hirschel B, Perrin L
Laboratoire central de virologie, Hôpital cantonal universitaire de Genève, HCUG.
Schweiz Med Wochenschr. 1995 Feb 25;125(8):341-6.
We report the history and clinical findings in 17 patients with primary HIV infection (PHI) diagnosed in the first 6 months of 1994. 9 of these patients were infected through heterosexual contacts, 5 were women with, as the only risk factor, sexual contacts with infected men. 10 of the 17 patients were symptomatic and the diagnosis of PHI was suspected in 8 of these patients at their first medical visit. However, the laboratory investigations were incomplete since p24 Ag was only requested for one patient and this led to a delay in diagnosis. Sera collected at the time of the first medical visit were available for 4 symptomatic patients, and in all of them p24 Ag was detected in the absence of HIV specific antibodies. These data underline the frequent occurrence of HIV transmission by the heterosexual route and the need to search for both specific antibodies and p24 Ag at the time of PHI.
我们报告了1994年上半年确诊的17例原发性HIV感染（PHI）患者的病史及临床检查结果。其中9例患者通过异性接触感染，5例为女性，其唯一的危险因素是与感染男性有性接触。17例患者中有10例出现症状，其中8例在首次就诊时就被怀疑患有PHI。然而，实验室检查并不全面，因为仅对1例患者进行了p24抗原检测，这导致了诊断延迟。4例有症状患者首次就诊时采集的血清可供检测，所有患者在尚无HIV特异性抗体时就检测到了p24抗原。这些数据强调了异性传播HIV的频繁发生，以及在原发性HIV感染时同时检测特异性抗体和p24抗原的必要性。
