Weder B, Oettli R
Klinik für Neurologie, Kantonsspital St. Gallen.
Schweiz Arch Neurol Psychiatr (1985). 1994;145(5):25-30.
The proper localization of regions of interest (ROIs) in Single Photon Emission Computed Tomography (SPECT) is an essential task. The limited spatial resolution makes it difficult to define regions by their structure. The particular problems are: 1) the difficulty to find the appropriate slice and its orientation in space; 2) the individual variation of the brain in dimension and shape. Referring to the basic work of Talairach and Szikla (1967), research is conducted to overcome these methodical problems in interpreting cranial computed tomography by using a proportional localization system. We analyzed four cases with focal motor seizures of different aetiology (tumour, hemorrhagic infarction, intracerebral hematoma, multifocal leukencephalopathy) by 99mTc HMPAO SPECT. The accumulation of the radiopharmacon was measured in ROIs which were delineated with the aid of the above mentioned system. The regions were selected in accordance to the autoradiographic study of penicillin induced epileptic seizures in animal experiments. Dependent on the severity of the clinical manifestation we were able to document the involvement of the supposed primary focus and of several related zones. We suggest that this approach should prove some usefulness in the examination of the interdependency of different brain areas.
在单光子发射计算机断层扫描（SPECT）中，对感兴趣区域（ROI）进行恰当定位是一项重要任务。有限的空间分辨率使得难以根据结构来界定区域。具体问题包括：1）难以找到合适的切片及其在空间中的方向；2）大脑在尺寸和形状上的个体差异。参照Talairach和Szikla（1967年）的基础研究，开展了相关研究，以通过使用比例定位系统来克服在解释头颅计算机断层扫描时的这些方法学问题。我们通过99mTc HMPAO SPECT分析了4例病因不同（肿瘤、出血性梗死、脑内血肿、多灶性白质脑病）的局灶性运动性癫痫病例。在借助上述系统划定的ROI中测量放射性药物的积聚情况。这些区域是根据动物实验中青霉素诱发癫痫发作的放射自显影研究选定的。根据临床表现的严重程度，我们能够证明假定的原发性病灶及几个相关区域受累。我们认为这种方法在检查不同脑区的相互依存关系方面应会证明有一定用处。
