Fröscher W, Neher K D
Neurologische Abteilung, Psychiatrisches Landeskrankenhaus Weissenau, Abteilung Psychiatrie I der Universität Ulm, Ravensburg.
Schweiz Arch Neurol Psychiatr (1985). 1994;145(5):4-7.
Frequent tonic-clonic seizures could probably lead to psychic disorders. In various studies a decrease in at least single functions of mental capability was found depending on the frequency of the seizures and/or the duration and/or the age of onset of the disease. The development of neuropsychological deficits depends on the type of seizures. Particularly BNS-seizures and the Lennox-Gastaut-syndrome have generally a poor prognosis concerning the intellectual development. Not only clinically manifest seizures but also subclinical discharges could disturb the psychic condition of epileptic patients. Epileptic seizures are probably a reason for neuronal damage in the hippocampus area. Psychogenic reactions and undesired effects of antiepileptic drugs have to be considered aside from functional disturbances due to epileptic seizures.
频繁的强直阵挛发作可能会导致精神障碍。在各项研究中，根据癫痫发作的频率和/或持续时间和/或发病年龄，发现至少有一项心理能力功能会下降。神经心理学缺陷的发展取决于癫痫发作的类型。特别是失神发作和 Lennox-Gastaut 综合征在智力发育方面通常预后较差。不仅临床明显的发作，而且亚临床放电也可能干扰癫痫患者的心理状态。癫痫发作可能是海马区神经元损伤的一个原因。除了癫痫发作引起的功能障碍外，还必须考虑精神性反应和抗癫痫药物的不良作用。
