Ueno Y, Shigenobu K, Nishio S
Toray Industries, Inc., Basic Research Laboratories, Kanagawa, Japan.
Arch Int Pharmacodyn Ther. 1994 Sep-Oct;328(2):191-9.
The inhibitory effect of beraprost on the transmembrane action potentials was compared with other cardioprotective drugs during hypoxia in guinea-pig isolated right ventricular muscle. Glibenclamide, like beraprost, inhibited the decrease of the action potential duration, but propanolol and diltiazem did not affect this decrease during hypoxia. In beraprost-treated preparations, the decrease of the myocardial K+ content during hypoxia was inhibited. Furthermore, beraprost prevented the action potential shortening during metabolic inhibition by 2,4-dinitrophenol. It is suggested that beraprost may inhibit the hypoxia- and 2,4-dinitrophenol-induced shortening of the action potential duration by preserving the muscular ATP level. Accordingly, beraprost may have beneficial effects both during hypoxia and metabolic inhibition.
在豚鼠离体右心室肌缺氧期间，将贝前列素对跨膜动作电位的抑制作用与其他心脏保护药物进行了比较。格列本脲与贝前列素一样，抑制动作电位时程的缩短，但普萘洛尔和地尔硫䓬在缺氧期间对这种缩短没有影响。在贝前列素处理的制剂中，缺氧期间心肌钾含量的降低受到抑制。此外，贝前列素可防止2,4-二硝基苯酚代谢抑制期间动作电位的缩短。提示贝前列素可能通过维持肌肉ATP水平来抑制缺氧和2,4-二硝基苯酚诱导的动作电位时程缩短。因此，贝前列素在缺氧和代谢抑制期间可能都具有有益作用。
