Roosen J U, Engel U, Jensen R H, Kvist E, Schou G
Department of Urology, Bispebjerg Hospital, University of Copenhagen, Denmark.
Br J Urol. 1994 Aug;74(2):160-4. doi: 10.1111/j.1464-410x.1994.tb16579.x.
To establish the prognostic value of a series of pre-operative, per-operative and histopathological parameters in relation to renal cell carcinoma (RCC).
This retrospective study involved a consecutive series of 76 patients (46 men and 30 women with a mean age of 65.3 years [range 44-91]) with a histologically confirmed diagnosis of RCC. Patients who were admitted over the period 1980-1984 were included. Data such as erythrocyte sedimentation rate (ESR), alkaline phosphatase level, histological tumour grade, degree of necrosis and presence of tumour vessels were evaluated in relation to actuarial survival.
The ESR and alkaline phosphatase level at the time of diagnosis of RCC, the histological tumour grade, degree of necrosis and presence of tumour vessels on angiography were all found to affect the actuarial length of survival significantly (P < or = 0.05 log-rank test). Macroscopic tumour demarcation estimated per-operatively by the surgeon or after surgery by the pathologist, microscopic demarcation, vascular density on histological examination, tumour diameter and vascular density on angiography were found not to affect actuarial survival significantly.
The value of establishing simple and reliable diagnostic indicators for patients with RCC is stressed.
确定一系列术前、术中及组织病理学参数对肾细胞癌（RCC）的预后价值。
本回顾性研究纳入了76例经组织学确诊为RCC的患者（46例男性，30例女性，平均年龄65.3岁[范围44 - 91岁]）。纳入了1980 - 1984年期间收治的患者。评估了诸如红细胞沉降率（ESR）、碱性磷酸酶水平、组织学肿瘤分级、坏死程度和肿瘤血管存在情况等数据与实际生存率的关系。
发现RCC诊断时的ESR和碱性磷酸酶水平、组织学肿瘤分级、坏死程度以及血管造影时肿瘤血管的存在情况均对实际生存时长有显著影响（P≤0.05，对数秩检验）。外科医生术中估计或病理学家术后估计的宏观肿瘤界限、微观界限、组织学检查时的血管密度、肿瘤直径以及血管造影时的血管密度均未对实际生存率产生显著影响。
强调了为RCC患者建立简单可靠诊断指标的价值。
