Irie F, Hashikawa T, Tai T, Seyama Y, Hirabayashi Y
Department of Physiological Chemistry and Nutrition, Faculty of Medicine, University of Tokyo, Japan.
Brain Res. 1994 Nov 28;665(1):161-6. doi: 10.1016/0006-8993(94)91169-x.
A newly developed mouse monoclonal antibody, GGR-41, was used to localize a novel species of gangliosides, GT1a alpha and GQ1b alpha, in the rat central nervous system. Intense immunoreactivity was found in the neuropil of the spinal cord dorsal horn, spinal trigeminal nucleus, solitary tract nucleus, superior colliculus, interpeduncular nucleus, hypothalamus and septal area. The results suggest that GT1a alpha and GQ1b alpha are expressed in the nerve terminals of a certain population of cholinergic fibers.
一种新开发的小鼠单克隆抗体GGR - 41被用于在大鼠中枢神经系统中定位一种新型神经节苷脂GT1aα和GQ1bα。在脊髓背角、三叉神经脊束核、孤束核、上丘、脚间核、下丘脑和隔区的神经毡中发现了强烈的免疫反应性。结果表明，GT1aα和GQ1bα在特定群体的胆碱能纤维的神经末梢中表达。
