Wolf H K, Wiestler O D
Institut für Neuropathologie der Universität Bonn.
Laryngorhinootologie. 1995 Feb;74(2):127-9. doi: 10.1055/s-2007-997705.
The surgical treatment of chronic epilepsies is increasing rapidly. A review of 279 surgical specimens of patients with chronic pharmaco-resistant epilepsies from the University of Bonn Medical Centre revealed specific histopathological findings in 89% of all well-preserved specimens. The most frequent focal lesions were low-grade brain tumours such as gangliogliomas, pilocytic astrocytomas and dysembryoplastic neuroepithelial tumours. Other common findings were glioneuronal and vascular malformations and Ammon's horn sclerosis. This suggests that chronic intractable epilepsies are frequently caused by structural alterations.
慢性癫痫的外科治疗正在迅速增加。对波恩大学医学中心279例慢性药物抵抗性癫痫患者的手术标本进行回顾发现，在所有保存完好的标本中，89%有特定的组织病理学发现。最常见的局灶性病变是低级别脑肿瘤，如神经节胶质瘤、毛细胞型星形细胞瘤和胚胎发育不良性神经上皮肿瘤。其他常见发现包括神经胶质神经元和血管畸形以及海马硬化。这表明慢性难治性癫痫常由结构改变引起。
