• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

膜联蛋白VI在人A431鳞状上皮癌细胞中具有肿瘤抑制活性。

Annexin VI has tumour-suppressor activity in human A431 squamous epithelial carcinoma cells.

作者信息

Theobald J, Hanby A, Patel K, Moss S E

机构信息

Department of Physiology, University College London, UK.

出版信息

Br J Cancer. 1995 Apr;71(4):786-8. doi: 10.1038/bjc.1995.152.

DOI:10.1038/bjc.1995.152
PMID:7710945
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2033739/
Abstract

In this study we show that heterologous expression of annexin VI in A431 squamous carcinoma cells caused a marked suppression of tumour cell growth when cells were cultured subcutaneously in nude mice. The tumours formed by the annexin VI+ A431 cells were morphologically and histologically similar to those formed by the wild-type cells.

摘要

在本研究中，我们发现，在裸鼠皮下培养时，膜联蛋白VI在A431鳞状癌细胞中的异源表达导致肿瘤细胞生长显著受抑。膜联蛋白VI阳性的A431细胞形成的肿瘤在形态学和组织学上与野生型细胞形成的肿瘤相似。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ee8/2033739/38ff4bd10ab9/brjcancer00050-0135-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ee8/2033739/38ff4bd10ab9/brjcancer00050-0135-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ee8/2033739/38ff4bd10ab9/brjcancer00050-0135-a.jpg

相似文献

1
Annexin VI has tumour-suppressor activity in human A431 squamous epithelial carcinoma cells.膜联蛋白VI在人A431鳞状上皮癌细胞中具有肿瘤抑制活性。
Br J Cancer. 1995 Apr;71(4):786-8. doi: 10.1038/bjc.1995.152.
2
Endocytosis occurs independently of annexin VI in human A431 cells.在人A431细胞中，内吞作用独立于膜联蛋白VI发生。
J Cell Biol. 1994 Feb;124(3):301-6. doi: 10.1083/jcb.124.3.301.
3
Expression of annexin VI in A431 carcinoma cells suppresses proliferation: a possible role for annexin VI in cell growth regulation.膜联蛋白VI在A431癌细胞中的表达抑制增殖：膜联蛋白VI在细胞生长调节中的可能作用。
Biochim Biophys Acta. 1994 Sep 29;1223(3):383-90. doi: 10.1016/0167-4889(94)90099-x.
4
Roles of cell adhesion molecules in tumor angiogenesis induced by cotransplantation of cancer and endothelial cells to nude rats.细胞黏附分子在癌与内皮细胞共移植诱导裸鼠肿瘤血管生成中的作用
Cancer Res. 2002 Nov 1;62(21):6289-96.
5
Effect of endogenous and exogenous EGF on the growth of EGF receptor-hyperproducing human squamous cell carcinoma implanted in nude mice.内源性和外源性表皮生长因子对裸鼠移植的表皮生长因子受体高表达人鳞状细胞癌生长的影响。
Br J Cancer. 1995 Oct;72(4):865-8. doi: 10.1038/bjc.1995.425.
6
Identification by differential display of annexin-VI, a gene differentially expressed during melanoma progression.通过差异显示鉴定膜联蛋白VI，一种在黑色素瘤进展过程中差异表达的基因。
Cancer Res. 1996 Sep 1;56(17):3855-8.
7
Functional analysis of the human annexin I and VI gene promoters.人膜联蛋白I和VI基因启动子的功能分析
Biochem J. 1998 Jun 15;332 ( Pt 3)(Pt 3):681-7. doi: 10.1042/bj3320681.
8
Superior localisation and imaging of radiolabelled monoclonal antibody E48 F(ab')2 fragment in xenografts of human squamous cell carcinoma of the head and neck and of the vulva as compared to monoclonal antibody E48 IgG.与单克隆抗体E48 IgG相比，放射性标记的单克隆抗体E48 F(ab')2片段在人头颈鳞状细胞癌和外阴异种移植瘤中的定位及成像效果更佳。
Br J Cancer. 1991 Jan;63(1):37-44. doi: 10.1038/bjc.1991.9.
9
Establishment and characterization of cisplatin-resistant human epidermoid carcinoma cell line, A431 cell.顺铂耐药人表皮样癌细胞系A431细胞的建立与鉴定
Chemotherapy. 1998 Nov-Dec;44(6):414-20. doi: 10.1159/000007153.
10
Clonal heterogeneity of a human functioning tumor which produces granulocyte colony-stimulating factor.
Jpn J Clin Oncol. 1990 Dec;20(4):349-55.

引用本文的文献

1
Revisiting the role of Annexins in membrane trafficking.重新审视膜联蛋白在膜运输中的作用。
Cell Mol Life Sci. 2025 Jun 13;82(1):230. doi: 10.1007/s00018-025-05780-z.
2
Pathobiological functions and clinical implications of annexin dysregulation in human cancers.膜联蛋白失调在人类癌症中的病理生物学功能及临床意义
Front Cell Dev Biol. 2022 Sep 28;10:1009908. doi: 10.3389/fcell.2022.1009908. eCollection 2022.
3
Annexin Animal Models-From Fundamental Principles to Translational Research. annexin 动物模型——从基础原理到转化研究。

本文引用的文献

1
Annexins: the problem of assessing the biological role for a gene family of multifunctional calcium- and phospholipid-binding proteins.膜联蛋白：评估一个多功能钙结合和磷脂结合蛋白基因家族生物学作用的问题
Biochim Biophys Acta. 1994 Apr 5;1197(1):63-93. doi: 10.1016/0304-4157(94)90019-1.
2
Structural evolution of the annexin supergene family.
Trends Genet. 1994 Jul;10(7):241-6. doi: 10.1016/0168-9525(94)90171-6.
3
Expression of annexin VI in A431 carcinoma cells suppresses proliferation: a possible role for annexin VI in cell growth regulation.膜联蛋白VI在A431癌细胞中的表达抑制增殖：膜联蛋白VI在细胞生长调节中的可能作用。
Int J Mol Sci. 2021 Mar 26;22(7):3439. doi: 10.3390/ijms22073439.
4
Implication of calcium activated RasGRF2 in Annexin A6-mediated breast tumor cell growth and motility.钙激活的RasGRF2在膜联蛋白A6介导的乳腺肿瘤细胞生长和运动中的作用
Oncotarget. 2019 Jan 4;10(2):133-151. doi: 10.18632/oncotarget.26512.
5
Annexin A6-A multifunctional scaffold in cell motility.膜联蛋白A6——细胞运动中的多功能支架蛋白
Cell Adh Migr. 2017 May 4;11(3):288-304. doi: 10.1080/19336918.2016.1268318. Epub 2017 Jan 6.
6
Role of annexin A6 in cancer.膜联蛋白A6在癌症中的作用。
Oncol Lett. 2015 Oct;10(4):1947-1952. doi: 10.3892/ol.2015.3498. Epub 2015 Jul 15.
7
Annexin A10 in human oral cancer: biomarker for tumoral growth via G1/S transition by targeting MAPK signaling pathways. annexin A10 在人类口腔癌中的作用：通过靶向 MAPK 信号通路调控 G1/S 期转化促进肿瘤生长的标志物。
PLoS One. 2012;7(9):e45510. doi: 10.1371/journal.pone.0045510. Epub 2012 Sep 17.
8
Differential Regulation of RasGAPs in Cancer.癌症中RasGAPs的差异调节
Genes Cancer. 2011 Mar;2(3):288-97. doi: 10.1177/1947601911407330.
9
Annexin A6-induced alterations in cholesterol transport and caveolin export from the Golgi complex.膜联蛋白A6诱导的胆固醇转运改变及小窝蛋白从高尔基体复合物的输出。
Traffic. 2007 Nov;8(11):1568-89. doi: 10.1111/j.1600-0854.2007.00640.x. Epub 2007 Sep 6.
10
Annexin A1 down-regulation in head and neck cancer is associated with epithelial differentiation status.头颈部癌症中膜联蛋白A1的下调与上皮分化状态相关。
Am J Pathol. 2004 Jan;164(1):73-9. doi: 10.1016/S0002-9440(10)63098-2.
Biochim Biophys Acta. 1994 Sep 29;1223(3):383-90. doi: 10.1016/0167-4889(94)90099-x.
4
Endocytosis occurs independently of annexin VI in human A431 cells.在人A431细胞中，内吞作用独立于膜联蛋白VI发生。
J Cell Biol. 1994 Feb;124(3):301-6. doi: 10.1083/jcb.124.3.301.
5
Primary structure of the human, membrane-associated Ca2+-binding protein p68 a novel member of a protein family.人膜相关钙结合蛋白p68的一级结构：蛋白质家族的一个新成员。
EMBO J. 1988 Jan;7(1):21-7. doi: 10.1002/j.1460-2075.1988.tb02779.x.
6
Modulation of Ca2+ release channel activity from sarcoplasmic reticulum by annexin VI (67-kDa calcimedin).膜联蛋白VI（67 kDa钙调素）对肌浆网Ca2+释放通道活性的调节作用
J Biol Chem. 1990 Sep 15;265(26):15894-9.
7
Expression of annexin VI (p68, 67 kDa-calelectrin) in normal human tissues: evidence for developmental regulation in B- and T-lymphocytes.
Histochemistry. 1991;96(5):405-12. doi: 10.1007/BF00315998.
8
Calphobindins (placental annexins) inhibit protein kinase C.钙结合蛋白（胎盘膜联蛋白）抑制蛋白激酶C。
J Biochem. 1992 Oct;112(4):552-6. doi: 10.1093/oxfordjournals.jbchem.a123937.
9
A growth-dependent post-translational modification of annexin VI.膜联蛋白VI的一种依赖于生长的翻译后修饰。
Biochim Biophys Acta. 1992 Nov 10;1160(1):120-6. doi: 10.1016/0167-4838(92)90045-f.
10
Annexin VI is required for budding of clathrin-coated pits.
Cell. 1992 Jul 24;70(2):283-91. doi: 10.1016/0092-8674(92)90102-i.