人类MSS1基因（HIV-1基因表达的正向调节因子）的一个同源物在非洲爪蟾卵母细胞中大量表达。

A homologue of the human MSS1 gene, a positive modulator of HIV-1 gene expression, is massively expressed in Xenopus oocytes.

作者信息

Nacken W, Kingsman A J, Kingsman S M, Sablitzky F, Sorg C

机构信息

Institute for Experimental Dermatology, Münster Medical School, Germany.

出版信息

Biochim Biophys Acta. 1995 Apr 4;1261(2):293-5. doi: 10.1016/0167-4781(95)00022-9.

DOI:10.1016/0167-4781(95)00022-9

PMID:7711076

Abstract

Here the nucleotide sequence of a Xenopus homologue of the human MSS1 gene, a positive modulator of the HIV-1 Tat mediated transactivation in mammalian cells, is presented. This gene is highly conserved and almost exclusively expressed in Xenopus oocytes. We speculate about a possible role of this gene in the HIV-1 Tat/TAR mediated transactivation in Xenopus oocytes.

摘要

本文展示了人类MSS1基因在非洲爪蟾中的同源基因的核苷酸序列，该基因是HIV-1 Tat在哺乳动物细胞中介导反式激活的正向调节因子。此基因高度保守，几乎只在非洲爪蟾卵母细胞中表达。我们推测了该基因在HIV-1 Tat/TAR介导的非洲爪蟾卵母细胞反式激活中可能发挥的作用。