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肽测序鉴定出MSS1（一种HIV反式激活因子Tat介导的反式激活的调节因子）为26S蛋白酶的亚基7。

Peptide sequencing identifies MSS1, a modulator of HIV Tat-mediated transactivation, as subunit 7 of the 26 S protease.

作者信息

Dubiel W, Ferrell K, Rechsteiner M

机构信息

Department of Biochemistry, University of Utah, School of Medicine, Salt Lake City 84132.

出版信息

FEBS Lett. 1993 Jun 1;323(3):276-8. doi: 10.1016/0014-5793(93)81356-5.

DOI:10.1016/0014-5793(93)81356-5
PMID:8500623
Abstract

Subunit 7 is an integral component of the human erythrocyte 26 S protease. Peptide sequence analysis reveals that 22 amino acids from the N-terminus of subunit 7 correspond exactly to the N-terminus of MSS1, a modulator of HIV gene expression. Additional internal peptides from subunit 7 obtained by CNBr cleavage also match 100% with the deduced amino acid sequence of MSS1. Based on the fact that directly sequenced peptides from subunit 7 are identical to more than 12% of the hypothetical translation product of MSS1, and the fact that the molecular weight of subunit 7 (49 kDa) corresponds to the predicted molecular weight of MSS1 (48,633 Da), we conclude that subunit 7 is MSS1.

摘要

亚基7是人类红细胞26S蛋白酶的一个组成部分。肽序列分析表明，亚基7 N端的22个氨基酸与HIV基因表达调节剂MSS1的N端完全一致。通过溴化氰裂解获得的亚基7的其他内部肽段也与MSS1的推导氨基酸序列100%匹配。基于亚基7直接测序的肽段与MSS1假设翻译产物的12%以上相同，以及亚基7的分子量（49 kDa）与MSS1的预测分子量（48,633 Da）相对应这一事实，我们得出结论：亚基7就是MSS1。

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Peptide sequencing identifies MSS1, a modulator of HIV Tat-mediated transactivation, as subunit 7 of the 26 S protease.肽测序鉴定出MSS1（一种HIV反式激活因子Tat介导的反式激活的调节因子）为26S蛋白酶的亚基7。
FEBS Lett. 1993 Jun 1;323(3):276-8. doi: 10.1016/0014-5793(93)81356-5.
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