Kuiper M, Peakman M, Farzaneh F
Department of Molecular Medicine, King's College School of Medicine and Dentistry, Denmark Hill, London, UK.
Gene Ther. 1995 Jan;2(1):7-15.
Major new developments in the understanding of the molecular mechanisms involved in immune recognition of self, and immune mediated rejection of foreign antigens, have resulted in the development of a variety of novel therapeutic strategies for the treatment of cancer. Cornerstones of the advances in this area have been the identification of tumour antigens and demonstration of immune recognition of neoplastic cells, most notably in malignant melanoma. There are now a number of clinical immune gene therapy trials in progress for the treatment of cancer by stimulating immune mediated rejection of malignant cells. Here we examine the evidence for immune recognition of ovarian tumour cells and the presence of putative ovarian tumour antigens as potential targets for immune gene therapy of ovarian carcinoma.
在对自身免疫识别和免疫介导的外来抗原排斥所涉及的分子机制的理解方面取得的重大新进展，已促成了多种用于治疗癌症的新型治疗策略的发展。该领域进展的基石是肿瘤抗原的鉴定以及肿瘤细胞免疫识别的证明，最显著的是在恶性黑色素瘤中。目前有多项临床免疫基因治疗试验正在进行，旨在通过刺激免疫介导的恶性细胞排斥来治疗癌症。在此，我们研究卵巢肿瘤细胞免疫识别的证据以及假定的卵巢肿瘤抗原的存在，这些抗原作为卵巢癌免疫基因治疗的潜在靶点。
