Zong G, Xiao G, Zhang Y
Department of Surgery, 81 Hospital of People's Liberation Army, Nanjing.
Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi. 1994 Sep;10(5):385-8.
Pharmacokinetic studies were carried out following systemic administration of ceftazidime in ten burn patients (TBSA 30%-60% and with full-thickness burn) and six healthy volunteers. Dynamic ceftazidime concentrations in blood, urine and blister fluid were analysed by HPLC. The results showed that the burned patients, especially during their shock phase, some pharmacokinetics parameters differed from that of normal volunteers, in that the volume of distribution (0.45 +/- 0.06 L/kg vs. 0.23 +/- 0.05 L/kg) and non-renal clearance of drug (30.54 +/- 21.97ml.min-1 vs. 11.08 +/- 4.91 ml.min-1) increased, but the elimination of half-life was prolonged. The result indicated that it was not necessary to increase the dosage of ceftazidime in extensive burns in the early period. Burn blister fluid concentrations were higher than MIC. Ranging from 1.004-21.62 micrograms/ml, indicating that systemic ceftazidime could penetrate second-degree burn tissue in the early postburn stage.
在10名烧伤患者（烧伤总面积30%-60%且为全层烧伤）和6名健康志愿者中，静脉注射头孢他啶后进行了药代动力学研究。采用高效液相色谱法分析血液、尿液和水疱液中头孢他啶的动态浓度。结果显示，烧伤患者，尤其是在休克期，一些药代动力学参数与正常志愿者不同，表现为分布容积（0.45±0.06L/kg对0.23±0.05L/kg）和药物非肾清除率（30.54±21.97ml·min-1对11.08±4.91ml·min-1）增加，但消除半衰期延长。结果表明，在大面积烧伤早期无需增加头孢他啶的剂量。烧伤水疱液浓度高于最低抑菌浓度，范围为1.004-21.62μg/ml，表明静脉注射头孢他啶可在烧伤后早期穿透深二度烧伤组织。
