慢性乙型肝炎患者阿莫西林/克拉维酸相关性胆汁淤积：一例报告

Amoxicillin/clavulanic acid associated cholestasis in a patient with chronic hepatitis B: a case report.

作者信息

Yang W G, Chan C Y, Lu C L, Tsay S H, Lee S D

机构信息

Department of Medicine, Veterans General Hospital-Taipei, Taiwan, R.O.C.

出版信息

Zhonghua Yi Xue Za Zhi (Taipei). 1995 Jan;55(1):64-8.

PMID:7712397

Abstract

We described a patient with history of chronic hepatitis B in whom cholestatic hepatitis occurred after amoxicillin/clavulanic acid (Augmentin) therapy, which to our knowledge is the first case reported in Asia. An atypical serology profile of hepatitis B virus (HBV) markers, demonstrated by negative hepatitis B surface antigen (HBsAg) associated with transient positivity of hepatitis B e antigen (HBeAg) and HBV DNA, was noted during the development of cholestasis.

摘要

我们描述了一名有慢性乙型肝炎病史的患者，该患者在接受阿莫西林/克拉维酸（奥格门汀）治疗后发生了胆汁淤积性肝炎，据我们所知，这是亚洲报道的首例此类病例。在胆汁淤积形成过程中，发现了乙型肝炎病毒（HBV）标志物的非典型血清学特征，表现为乙型肝炎表面抗原（HBsAg）阴性，同时乙型肝炎e抗原（HBeAg）和HBV DNA短暂阳性。