Bye A M, Parle J, Haindl W
Department of Paediatric Neurology, Prince of Wales Children's Hospital, Sydney.
Clin Exp Neurol. 1993;30:117-26.
We aimed to determine the site of ictal foci and the pathogenesis of seizures in 4 infants with intractable seizures. The patients were studied using simultaneous video and electroencephalographic (EEG) monitoring, structural studies and ictal and interictal single photon emission computed tomography (SPECT). Ictal neurophysiology showed multifocal seizure propagation in Patients 1 and 2 and generalised abnormal electrical patterns in Patients 2, 3 and 4. Magnetic resonance imaging (MRI) demonstrated a focal abnormality in Patient 4. SPECT studies showed focal or multifocal increased uptake in 3 subjects (Patients 1,3,4) and increased uptake in the thalamic and basal ganglia regions of 2 subjects (Patients 2,3). SPECT studies contributed to an understanding of the pathogenesis of seizure initiation and propagation in the 4 patients studied.
我们旨在确定4例难治性癫痫婴儿的发作灶部位及癫痫发病机制。对这些患者进行了同步视频和脑电图（EEG）监测、结构研究以及发作期和发作间期单光子发射计算机断层扫描（SPECT）。发作期神经生理学显示，患者1和患者2存在多灶性癫痫发作传播，患者2、3和4存在全身性异常电活动模式。磁共振成像（MRI）显示患者4存在局灶性异常。SPECT研究显示3例受试者（患者1、3、4）存在局灶性或多灶性摄取增加，2例受试者（患者2、3）丘脑和基底节区摄取增加。SPECT研究有助于理解所研究的4例患者癫痫发作起始和传播的发病机制。
