Zhou Z G, Luo H B, Tang W L
Institute of Metabolism & Endocrinology, Hunan Medical University, Changsha.
Zhonghua Nei Ke Za Zhi. 1994 Oct;33(10):661-2.
To investigate antidiuretic effect of indapamide, ten patients with central diabetes insipidus (CDI) were observed with the treatment of 2.5-7.5 mg of indapamide per day. After the third day of therapy, their mean daily urine output reduced by about 50%, and urine osmolality increased 1.36 times. No further change was seen in urine volume and urine osmolality on the sixth day of treatment. This antidiuretic effect was similar to that of 50-75 mg dihydrochlorothiazide per day. No adverse reaction was observed in blood pressure and serum potassium concentration during indapamide therapy. These data suggest that indapamide may be a new drug in the management of CDI.
为研究吲达帕胺的抗利尿作用，对10例中枢性尿崩症（CDI）患者进行观察，给予每日2.5 - 7.5毫克吲达帕胺治疗。治疗第三天后，他们的日均尿量减少约50%，尿渗透压增加1.36倍。治疗第六天，尿量和尿渗透压未见进一步变化。这种抗利尿作用与每日50 - 75毫克氢氯噻嗪的作用相似。吲达帕胺治疗期间，血压和血清钾浓度未观察到不良反应。这些数据表明，吲达帕胺可能是治疗中枢性尿崩症的一种新药。
