评估环境暴露和化学处理的大西洋小鳕中CYP1A mRNA诱导性的组内变异。
Assessment of within-group variation in CYP1A mRNA inducibility in environmentally exposed and chemically treated Atlantic tomcod.
作者信息
Courtenay S, Williams P J, Grunwald C, Konkle B, Ong T L, Wirgin I I
机构信息
Canadian Department of Fisheries and Oceans, Moncton, New Brunswick.
出版信息
Environ Health Perspect. 1994 Dec;102 Suppl 12(Suppl 12):85-90. doi: 10.1289/ehp.94102s1285.
CYP1A gene expression has been implicated in the processing of environmental procarcinogens and levels of variation in CYP1A mRNA expression are high in both environmentally exposed and chemically treated Atlantic tomcod. The objective of this study was to evaluate the effects of physical and biological parameters such as temperature, sex, and reproductive state on within-group variation in CYP1A mRNA induction. Levels of variation in CYP1A mRNA expression were directly correlated with mean levels of gene induction. Our results indicate that sex and reproductive state, but not temperature, had significant effects on CYP1A mRNA inducibility in tomcod; however, these parameters did not account for all interindividual variation in CYP1A inducibility. Other intrinsic biological factors, such as genetic polymorphisms in molecular pathways leading to CYP1A induction, may contribute to the high levels of interindividual variation in CYP1A inducibility in Atlantic tomcod.
细胞色素P450 1A（CYP1A）基因表达与环境前致癌物的代谢有关，在环境暴露和化学处理的大西洋小鳕鱼中，CYP1A mRNA表达的变异水平都很高。本研究的目的是评估温度、性别和生殖状态等物理和生物学参数对CYP1A mRNA诱导组内变异的影响。CYP1A mRNA表达的变异水平与基因诱导的平均水平直接相关。我们的结果表明，性别和生殖状态而非温度对小鳕鱼的CYP1A mRNA诱导能力有显著影响；然而，这些参数并不能解释CYP1A诱导能力的所有个体间变异。其他内在生物学因素，如导致CYP1A诱导的分子途径中的基因多态性，可能导致大西洋小鳕鱼CYP1A诱导能力个体间变异水平较高。
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