Kato H, Araki T, Itoyama Y, Kogure K
Department of Neurology, Tohoku University School of Medicine, Sendai, Japan.
Eur J Pharmacol. 1995 Jan 5;272(1):107-10. doi: 10.1016/0014-2999(94)00694-3.
We examined the effects of rolipram, a cyclic AMP-selective phosphodiesterase inhibitor, on cerebral ischemia-induced neuronal damage in Mongolian gerbils. Transient forebrain ischemia was induced by 3-min occlusion of bilateral common carotid arteries. Rolipram, at a dose of 0.3 or 3 mg/kg, was injected i.p. 30 min before ischemia. Histopathological observations showed that neuronal damage to the hippocampal CA1 subfield, which was seen 7 days after ischemia in vehicle-treated animals, was reduced in animals treated with the higher dose of rolipram.
我们研究了环磷腺苷选择性磷酸二酯酶抑制剂咯利普兰对蒙古沙鼠脑缺血诱导的神经元损伤的影响。通过结扎双侧颈总动脉3分钟诱导短暂性前脑缺血。在缺血前30分钟腹腔注射剂量为0.3或3mg/kg的咯利普兰。组织病理学观察表明，在接受 Vehicle 处理的动物中，缺血7天后可见的海马CA1亚区神经元损伤，在接受较高剂量咯利普兰处理的动物中有所减轻。
