Camins A, Diez-Fernandez C, Pujadas E, Camarasa J, Escubedo E
Unidad de Farmacología y Farmacognosia, Universidad de Barcelona, Facultad de Farmacia, Zona Universidad Pedralbes, Barcelona, Spain.
Eur J Pharmacol. 1995 Jan 16;272(2-3):289-92. doi: 10.1016/0014-2999(94)00652-n.
Ro 5-4864 (4-chlorodiazepam), PK 11195 (1-(2-chlorophenyl)-1,3-dihydro-1-methyl-propyl)isoquinoline carboxamide) and diazepam inhibit, in a concentration-dependent way, the proliferation of V79 Chinese hamster lung cells (IC50 values were: 65.0 +/- 3.73 microM, 57.70 +/- 4.75 microM and 106.80 +/- 8.89 microM, respectively) without being cytotoxic. This antiproliferative effect is mediated by mitosis arrest in the G2 + M stage without affecting DNA synthesis and seems unrelated to a specific interaction of these drugs with the peripheral-type benzodiazepine receptor.
Ro 5-4864（4-氯地西泮）、PK 11195（1-(2-氯苯基)-1,3-二氢-1-甲基丙基）异喹啉甲酰胺）和地西泮以浓度依赖性方式抑制V79中国仓鼠肺细胞的增殖（IC50值分别为：65.0±3.73微摩尔、57.70±4.75微摩尔和106.80±8.89微摩尔），且无细胞毒性。这种抗增殖作用是由G2+M期的有丝分裂停滞介导的，不影响DNA合成，并且似乎与这些药物与外周型苯二氮䓬受体的特异性相互作用无关。
