LeBelle M J, Savard C, Dawson B A, Black D B, Katyal L K, Zrcek F, By A W
Forensic Science Laboratory, Haryana Madhybam (Karnal), India.
Forensic Sci Int. 1995 Feb 28;71(3):215-23. doi: 10.1016/0379-0738(94)01669-0.
The enantiomers of the related substances methamphetamine, ephedrine, pseudoephedrine and methcathinone were determined by both gas chromatography after derivatization and by nuclear magnetic resonance using a chiral solvating agent. For GC the substances were derivatized with (R)-(+)-alpha-methoxy-alpha-(trifluoromethyl)phenylacetic acid (MTPA) to give diasteromeric derivatives. Resolution (baseline) of at least 1.6 was obtained between all derivatives. NMR determination of the enantiomers was conducted in a chiral environment by the addition of the chiral solvating agent, (R)-(+)-1,1'-bi-2-naphthol, to NMR solutions of the substances. Racemization of methcathinone was demonstrated to be facile by exposure to alkaline solutions for varying periods of time. Enantiomeric ratios of some products derived from the oxidation of ephedrine were determined.
通过衍生化后的气相色谱法以及使用手性溶剂化剂的核磁共振法，对相关物质甲基苯丙胺、麻黄碱、伪麻黄碱和甲卡西酮的对映体进行了测定。对于气相色谱法，这些物质用（R）-（+）-α-甲氧基-α-（三氟甲基）苯乙酸（MTPA）进行衍生化，以得到非对映体衍生物。所有衍生物之间的分离度（基线）至少为1.6。对映体的核磁共振测定是在加入手性溶剂化剂（R）-（+）-1,1'-联萘酚的手性环境中，对这些物质的核磁共振溶液进行的。通过将甲卡西酮暴露于碱性溶液中不同时间，证明其外消旋化很容易。测定了一些由麻黄碱氧化得到的产物的对映体比例。
