Tartter P I
Department of Surgery, Mount Sinai Medical Center, New York, NY 10029, USA.
Immunol Invest. 1995 Jan-Feb;24(1-2):277-88. doi: 10.3109/08820139509062778.
Blood transfusion is associated with numerous clinical phenomena attributable to immune suppression. Homologous blood transfusion is associated with declines in lymphocyte numbers and inhibition of lymphocyte function. In dialysis patients this immune suppression is accompanied by prolongation of survival of subsequently transplanted allografts. For patients undergoing surgical procedures, the receipt of homologous blood increases the risk of postoperative infectious complications. Patients with malignancies have significantly increased recurrence and mortality rates when removal of their tumor is accompanied by the administration of blood. The clinical course of Crohn's disease may be beneficially influenced by transfusion at the time of resection of diseased bowel. Women suffering recurrent abortion may carry to term following transfusion of spouse leukocytes. Experimental studies, in addition to replicating the clinical studies, have documented that transfusion inhibits wound healing. Blood transfusion, the oldest form of transplantation, causes profound and prolonged alterations in immune function which result in clinical phenomena which can be either beneficial or detrimental to the recipient.
输血与许多归因于免疫抑制的临床现象相关。同种异体输血与淋巴细胞数量减少和淋巴细胞功能抑制有关。在透析患者中，这种免疫抑制伴随着随后移植的同种异体移植物存活时间的延长。对于接受外科手术的患者，接受同种异体血会增加术后感染并发症的风险。患有恶性肿瘤的患者在切除肿瘤并输血时，复发率和死亡率会显著增加。在切除患病肠段时输血可能会对克罗恩病的临床病程产生有益影响。反复流产的女性在输注配偶白细胞后可能会足月分娩。实验研究除了重复临床研究外，还证明输血会抑制伤口愈合。输血作为最古老的移植形式，会导致免疫功能发生深刻而持久的改变，从而产生对接受者有益或有害的临床现象。
