Davey R J
National Institutes of Health, Bethesda, Maryland, USA.
Immunol Invest. 1995 Jan-Feb;24(1-2):431-4. doi: 10.3109/08820139509062791.
Transfusion-associated graft-versus-host disease (TA-GVHD) is a rare but lethal disorder caused when viable donor lymphocytes engraft and proliferate in a susceptible transfusion recipient. Patients with immune deficiency disorders, hematologic malignancies and bone marrow transplants are at risk to TA-GVHD, as are premature newborns and transfusion recipients who are HLA heterozygous for an HLA-haplotype that is shared with an HLA homozygous donor. Irradiation of blood components with 2500 cGy will inactivate donor lymphocytes and prevent TA-GVHD. Platelets and granulocytes are not functionally impaired by this radiation dose, but red cells sustain detectable damage. Red cell units irradiated and stored for 42 days have significantly higher supernatant recovery of chromium-51 labeled cells is sub-optimal. Based on these data, the maximum permissible storage time for irradiated red cells has been reduced to 28 days.
输血相关移植物抗宿主病（TA-GVHD）是一种罕见但致命的疾病，当有活力的供体淋巴细胞在易患输血受者体内植入并增殖时就会引发该病。免疫缺陷疾病患者、血液系统恶性肿瘤患者和骨髓移植患者有患TA-GVHD的风险，早产新生儿以及与HLA纯合供体共享HLA单倍型的HLA杂合输血受者也有此风险。用2500厘戈瑞照射血液成分会使供体淋巴细胞失活并预防TA-GVHD。该辐射剂量不会对血小板和粒细胞的功能造成损害，但红细胞会受到可检测到的损伤。照射并储存42天的红细胞单位，其铬-51标记细胞的上清液回收率显著更高，不过并不理想。基于这些数据，照射红细胞的最长允许储存时间已减至28天。
