Kovacs K, Stefaneanu L, Horvath E, Buchfelder M, Fahlbusch R, Becker W
Department of Pathology, St. Michael's Hospital, University of Toronto, Ontario, Canada.
J Neurosurg. 1995 May;82(5):886-90. doi: 10.3171/jns.1995.82.5.0886.
A 14-year-old girl presented with a rapidly growing, invasive prolactin-producing pituitary tumor that failed to respond to dopamine agonist medication. Histological, immunocytochemical, and ultrastructural studies of the surgically removed tissue revealed a pleomorphic, chromophobic, or slightly acidophilic pituitary tumor that was immunoreactive for prolactin and that, according to electron microscopy, consisted of atypical lactotrophs showing no evidence of cell shrinkage. In situ hybridization demonstrated large amounts of prolactin messenger ribonucleic acid (mRNA), moderate amounts of estrogen receptor mRNA and dopamine (D2) receptor mRNA, and an absence of growth hormone mRNA in the tumor cells. Because D2 receptor mRNA was present in the tumor, causes other than D2 receptor loss may have been responsible for the resistance of the lactotrophs to dopamine agonist administration.
一名14岁女孩患有快速生长的侵袭性泌乳素分泌型垂体瘤，对多巴胺激动剂药物治疗无反应。对手术切除组织进行的组织学、免疫细胞化学和超微结构研究显示，这是一种多形性、嫌色性或轻度嗜酸性垂体瘤，对泌乳素呈免疫反应性，根据电子显微镜观察，由非典型泌乳细胞组成，未显示细胞萎缩迹象。原位杂交显示肿瘤细胞中有大量泌乳素信使核糖核酸（mRNA）、适量雌激素受体mRNA和多巴胺（D2）受体mRNA，且无生长激素mRNA。由于肿瘤中存在D2受体mRNA，泌乳细胞对多巴胺激动剂给药产生耐药性的原因可能是D2受体缺失以外的其他因素。
